Staff Victoria I. Bunik
Department
Department of Biokinetics
Phone
+7 (495) 939-44-84
Email
bunik@belozersky.msu.ru
Room
Building B, room 622
VICTORIA I. BUNIK, Leading scientist of the A.N. Belozersky Institute of Physico-chemical Biology and Professor of the Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University; reads the course of lectures “Enzymology: Mechanisms of catalysis”; supervises the course (B.Sc.), diploma (M.Sc.), and PhD works of students; published over 90 papers in the peer-reviewed journals and over 40 conference presentations; principal investigator of grants supported by Russian Foundation of Basic Research and/or International Foundations; reviewer of the Russian and international biochemical and biomedical journals; member of the expert commission of the student conference “Lomonosov”; member of the exam committees.

Articles

  1. Overton Elliot, Emelyanova Alina, Bunik Victoria I. (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling. FRONTIERS IN NUTRITION, >>

  2. Aleshin Vasily A., Kaehne Thilo, Maslova Maria V., Graf Anastasia V., Bunik Victoria I. (2024) Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport. International Journal of Molecular Sciences, >>

  3. Граф А.В., Артюхов А.В., Соловьева О.Н., Ксенофонтов А.Л., Буник В.И. (2024) Совместное введение крысам метформина и ампролиума влияет на метаболизм свободных аминокислот в мозге, изменяя поведение и частоту сердечных сокращений. Биохимия,

  4. Graf Anastasia V., Artiukhov Artem V., Solovjeva Olga N., Ksenofontov Alexander L., Bunik Victoria I. (2024) Combined Administration of Metformin and Amprolium to Rats Affects Metabolism of Free Amino Acids in the Brain, Altering Behavior, and Heart Rate. Biochemistry (Moscow), >>

  5. Артюхов А.В., Соловьева О.Н., Балашова Н.В., Сидорова О.П., Граф А.В., Буник В.И. (2024) Фармакологические дозы тиамина улучшают состояние пациентов с невропатией Шарко-Мари-Тута, изменяя уровень тиаминдифосфата и регуляцию зависимых от него ферментов. Биохимия, >>

  6. Artiukhov Artem V., Solovjeva Olga N., Balashova Natalia V., Sidorova Olga P., Graf Anastasia V., Bunik Victoria I. (2024) Pharmacological Doses of Thiamine Benefit Patients with the Charcot–Marie–Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Moscow), >>

  7. Bunik VI (2024) Supramolecular Protein Assemblies: Building Blocks, Organism- or Cell-Specific Varieties, and Significance. Biomolecules, >>

  8. Bunik V.I. (2024) A challenging interplay between basic research, technologies and medical education to provide therapies based on disease mechanisms. Frontiers in Medicine, >>

  9. Aleshin Vasily A., Graf Anastasia V., Artiukhov Artem V., Ksenofontov Alexander L., Zavileyskiy Lev G., Maslova Maria V., Bunik Victoria I. (2023) Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain. International Journal of Molecular Sciences, >>

  10. Алешин В.А., Буник В.И. (2023) Белок-белковые интерфейсы как мишени лекарств: общий для пиридоксаль-5′-фосфат-зависимых ферментов мотив для получения кофермента от его продуцентов. Биохимия, >>

  11. Aleshin Vasily A., Bunik Victoria I. (2023) Protein–Protein Interfaces as Druggable Targets: A Common Motif of the Pyridoxal-5′-Phosphate-Dependent Enzymes to Receive the Coenzyme from Its Producers. Biochemistry (Moscow), >>

  12. Алешин В.А., Сибирякина Д.A., Казанцев А.В., Граф А.В., Буник В.И. (2023) Ацилирование белков мозга крысы изменяется при специфическом ингибировании пируватдегидрогеназы in vivo. Биохимия, >>

  13. Aleshin Vasily A., Sibiryakina Daria A., Kazantsev Alexey V., Graf Anastasia V., Bunik Victoria I. (2023) Acylation of the Rat Brain Proteins is Affected by the Inhibition of Pyruvate Dehydrogenase in vivo. Biochemistry (Moscow), >>

  14. Bunik VI (2023) Editorial: Experts' opinion in medicine 2022. Frontiers in Medicine, >>

  15. Bunik Victoria (2023) The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes. Biology, >>

  16. Weidinger Adelheid, Milivojev Nadja, Hosmann Arthur, Duvigneau J.Catharina, Szabo Csaba, Törö Gabor, Rauter Laurin, Vaglio-Garro Annette, Mkrtchyan Garik V., Trofimova Lidia, Sharipov Rinat R., Surin Alexander M., Krasilnikova Irina A., Pinelis Vsevolod G (2023) Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death. Redox Biology, >>

  17. Artiukhov Artem V., Aleshin Vasily A., Karlina Irina S., Kazantsev Alexey V., Sibiryakina Daria A., Ksenofontov Alexander L., Lukashev Nikolay V., Graf Anastasia V., Bunik Victoria I. (2022) Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain. International Journal of Molecular Sciences, >>

  18. Zavileyskiy Lev G., Aleshin Vasily A., Kaehne Thilo, Karlina Irina S., Artiukhov Artem V., Maslova Maria V., Graf Anastasia V., Bunik Victoria I. (2022) The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy. International Journal of Molecular Sciences, >>

  19. Aleshin Vasily A., Bunik Victoria I., Bruch Eduardo M., Bellinzoni Marco (2022) Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase. International Journal of Molecular Sciences, >>

  20. Bunik Victoria I., Artiukhov Artem V., Kazantsev Alexey V., Aleshin Vasily A., Boyko Alexandra I., Ksenofontov Alexander L., Lukashev Nikolay V., Graf Anastasia V. (2022) Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses. Frontiers in Chemistry, >>

  21. Boyko Alexandra I., Karlina Irina S., Zavileyskiy Lev G., Aleshin Vasily A., Artiukhov Artem V., Kaehne Thilo, Ksenofontov Alexander L., Ryabov Sergey I., Graf Anastasia V., Tramonti Angela, Bunik Victoria I. (2022) Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation. Frontiers in Medicine, >>

  22. Graf Anastasia V., Maslova Maria V., Artiukhov Artem V., Ksenofontov Alexander L., Aleshin Vasily A., Bunik Victoria I. (2022) Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age. International Journal of Molecular Sciences, >>

  23. Artiukhov Artem V., Graf Anastasia V., Kazantsev Alexey V., Boyko Alexandra I., Aleshin Vasily A., Ksenofontov Alexander L., Bunik Victoria I. (2022) Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation. Pharmaceuticals, >>

  24. Bunik Victoria, Aleshin Vasily, Nogues Isabel, Kähne Thilo, Parroni Alessia, Contestabile Roberto, Salvo Martino Luigi, Graf Anastasia, Tramonti Angela (2022) Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo. Journal of Neurochemistry, >>

  25. Balashova Natalia V., Zavileyskiy Lev G., Artiukhov Artem V., Shaposhnikov Leonid A., Sidorova Olga P., Tishkov Vladimir I., Tramonti Angela, Pometun Anastasia A., Bunik Victoria I. (2022) Efficient Assay and Marker Significance of NAD+ in Human Blood. Frontiers in Medicine, >>

  26. Ташлицкий В.Н., Артюхов А.В., Федорова Н.В., Суконников М.А., Ксенофонтов А.Л., Буник В.И., Баратова Л.А. (2022) Определение 2‑оксокислот в экстрактах мозга крыс с помощью высокоэффективной жидкостной хроматографии. Биохимия, >>

  27. Tashlitsky Vadim N., Artiukhov Artem V., Fedorova Natalia V., Sukonnikov Maxim A., Ksenofontov Alexander L., Bunik Victoria I., Baratova Ludmila A. (2022) Analysis of Content of 2-Oxoacids in Rat Brain Extracts Using High-Performance Liquid Chromatography. Biochemistry (Moscow), >>

  28. Pokrovsky Vadim S., Qoura Louay Abo, Morozova Elena, Bunik Victoria I. (2022) Predictive markers for efficiency of the amino-acid deprivation therapies in cancer. Frontiers in Medicine, >>

  29. Bunik Victoria I., Habak Claudine (2022) Editorial: Women in science - translational medicine 2021. Frontiers in Medicine, >>

  30. Zavileyskiy Lev, Bunik Victoria (2022) Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes. Biomolecules, >>

  31. Artiukhov Artem V., Kolesanova Ekaterina F., Boyko Aleksandra I., Chashnikova Anastasiya A., Gnedoy Sergei N., Kaehne Thilo, Ivanova Daria A., Kolesnichenko Alyona V., Aleshin Vasily A., Bunik Victoria I. (2021) Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues. Biomolecules, >>

  32. Aleshin Vasily A., Graf Anastasia V., Artiukhov Artem V., Boyko Alexandra I., Ksenofontov Alexander L., Maslova Maria V., Nogués Isabel, di Salvo Martino L., Bunik Victoria I. (2021) Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model. Pharmaceuticals, >>

  33. Aleshin Vasily A., Artiukhov Artem V., Kaehne Thilo, Graf Anastasia V., Bunik Victoria I. (2021) Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293. International Journal of Molecular Sciences, >>

  34. Aleshin VA, Zhou X., Krishnan S., Karlsson A., Bunik VI (2021) Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing metabolism of 2-oxoglutarate/glutamate. Frontiers in genetics, >>

  35. Boyko A., Tsepkova P., Aleshin V., Artiukhov A., Mkrtchyan G., Ksenofontov A., Baratova L., Ryabov S., Graf A., Bunik V. (2021) Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance. Frontiers in Molecular Neuroscience, >>

  36. Artiukhov Artem V., Kazantsev Alexey V., Lukashev Nikolay V., Bellinzoni Marco, Bunik Victoria I. (2021) Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates. Frontiers in Chemistry, >>

  37. Graf A., Ksenofontov A., Bunik V. (2021) Inhibition of 2-OxoglutarateDehydrogenase as a Chemical Model of Acute Hypobaric Hypoxia. Frontiers in Medicine, >>

  38. Barile Anna, Mills Philippa, di Salvo Martino L., Graziani Claudio, Bunik Victoria, Clayton Peter, Contestabile Roberto, Tramonti Angela (2021) Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5$\prime$-Phosphate Oxidase-Dependent Epilepsy. International Journal of Molecular Sciences, >>