Staff Vladimir P. Skulachev

A. N. Belozersky Research Instituteof Physico-Chemical Biology MSU

  2. A. N. Belozersky Research Institute, MSU, Russia
  3. Departments and Laboratories
  4. Staff

Vladimir P. Skulachev

Phone
8 (495) 939-55-30
Email
skulach@belozersky.msu.ru
Room
Bld. A, room 418

Academician of the Russian Academy of Sciences, Professor, Doctor of Biological Sciences, V.P. Skulachev heads the Belozersky Physico-Chemical Biology Institute at Lomonosov Moscow State University, and is the dean of the Faculty of Bioengineering and Bioinformatics which was organized in 2002 at Lomonosov Moscow State University.

Main areas of research and main results:

V.P. Skulachev is an outstanding Russian biochemist of world renown, the author of more than 750 scientific articles. He described the phenomenon of intermembrane electron transfer, discovered the effect of thermoregulatory uncoupling of oxidation and phosphorylation, proved the conversion of chemical and light energy into an electrical form by means of intracellular membrane proteins, predicted and then demonstrated the cable transport of electrical energy in the membranes of living organisms, clarified the biological significance of the nonequilibrium distribution of Na+ and K+ ions between cell and environment, discovered a new type of energetics of living organisms - the "sodium cycle". In recent years, the scientific activity of V.P. Skulachev is associated with the study of the molecular mechanisms of aging processes.

Educational activity:

For more than 50 years, V.P. Skulachev gives a course of lectures on bioenergetics for undergraduate and graduate students, included in the mandatory program at the Faculty of Biology and at the Faculty of Bioengineering and Bioinformatics at Lomonosov Moscow State University. During all this time, Skulachev is the organizer and leader of the Moscow City Scientific Seminar. Since 2003 V.P. Skulachev is the organizer and leader of the interdisciplinary biomedical project 'Skulachev Ions', which brings together about 300 domestic and foreign scientists from dozens of research laboratories and universities. The purpose of this project is to develop innovative drugs aimed at combating various age-related pathologies of the living organisms and slowing down the aging process. The project is based on the ideas put forward by V.P. Skulachev back in 1969.

Academic activity:

For more than 20 years, V.P. Skulachev is the editor-in-chief of the scientific journal Biochemistry-Moscow, which has become one of the most cited biological journals in Russia in recent years. He is a member of the editorial boards of FEBS Letters, IUBMB-Life, Journal of Bioenergetics and Biomembranes, Biophysics Reviews and Letters, Cell Cycle, The Open Aging Journal. V.P. Skulachev is the Honorary President of the Russian Society of Biochemists and Molecular Biologists, member of the European Academy and President of the Club of Russian Members of the European Academy.

Scientific awards:

V.P. Skulachev is a laureate of a number of prestigious Russian and international awards.

Articles

  1. Vyssokikh Mikhail Yu, Vigovskiy Maksim A., Philippov Vladislav V., Boroday Yakov R., Marey Mariya V., Grigorieva Olga A., Vepkhvadze Tatiana F., Kurochkina Nadezhda S., Manukhova Ludmila A., Efimenko Anastasiya Yu, Popov Daniil V., Skulachev Vladimir P. (2024) Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle. Biochemistry (Moscow), >>

  2. Skulachev VP, Vyssokikh MY, Chernyak BV, Averina OA, Andreev-Andrievskiy AA, Zinovkin RA, Lyamzaev KG, Marey MV, Egorov MV, Frolova OJ, Zorov DB, Skulachev MV, Sadovnichii VA (2023) Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks. Scientific reports, >>

  3. Skulachev V.P., Vyssokikh M.Y., Chernyak B.V., Mulkidjanian A.Y., Skulachev M.V., Shilovsky G.A., Lyamzaev K.G., Borisov V.B., Severin F.F., Sadovnichii V.A. (2023) Six Functions of Respiration: Isn’t It Time to Take Control over ROS Production in Mitochondria, and Aging Along with It?. International Journal of Molecular Sciences, >>

  4. Muntyan Maria S., Viryasov Mikhail B., Sorokin Dimitry Y., Skulachev Vladimir P. (2022) Sodium Energetic Cycle in the Natronophilic Bacterium Thioalkalivibrio versutus. International Journal of Molecular Sciences, >>

  5. Шиловский Г.А., Путятина Т.С., Моргунова Г.В., Селиверстов А.В., Ашапкин В.В., Сорокина Е.В., Марков А.В., Скулачев В.П. (2021) Регуляция белков циркадных ритмов и Nrf2-опосредованной антиоксидантной защиты: двойная роль киназы гликогенсинтазы 3. Биохимия, >>

  6. Shilovsky G.A., Putyatina T.S., Morgunova G.V., Seliverstov A.V., Ashapkin V.V., Sorokina E.V., Markov A.V., Skulachev V.P. (2021) A crosstalk between the biorhythms and gatekeepers of longevity: Dual role of glycogen synthase kinase-3. Biochemistry (Moscow), >>

  7. Vays V.B., Vangeli I.M., Eldarov C.M., Holtze S., Hildebrandt T.B., Bakeeva L.E., Skulachev V.P. (2021) Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Heterocephalus glaber) as revealed by electron microscopy: potential role in continual maintenance of muscle activity. AGING-US, >>

  8. Holtze Susanne, Gorshkova Ekaterina, Braude Stan, Cellerino Alessandro, Dammann Philip, Hildebrandt Thomas B., Hoeflich Andreas, Hoffmann Steve, Koch Philipp, Terzibasi Tozzini Eva, Skulachev Maxim, Skulachev Vladimir P., Sahm Arne (2021) Alternative Animal Models of Aging Research. Frontiers in Molecular Biosciences, >>

  9. Goleva Tatyana N., Lyamzaev Konstantin G., Rogov Anton G., Khailova Ljudmila S., Epremyan Khoren K., Shumakovich Galina P., Domnina Lidia V., Ivanova Olga Yu, Marmiy Natalia V., Zinevich Tatiana V., Esipov Dmitry S., Zvyagilskaya Renata A., Skulachev Vlad (2020) Mitochondria-targeted 1,4-naphthoquinone (SkQN) is a powerful prooxidant and cytotoxic agent. Biochimica et Biophysica Acta - Bioenergetics, >>

  10. Titova Ekaterina V., Shagieva Galina, Ivanova Olga Y., Domnina Lidiya, Domninskaya Maria, Strelkova Olga, Khromova Natalya, Kopnin Pavel, Chernyak Boris, Skulachev Vladimir, Dugina Vera (2018) Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth. Cell Cycle, >>

  11. Lyamzaev KG, Tokarchuk AV, Panteleeva AA, Mulkidjanian AY, Skulachev VP, Chernyak BV (2018) Induction of autophagy by depolarization of mitochondria. Autophagy, >>

  12. Zakharova Vlada V., Pletjushkina Olga Yu, Galkin Ivan I., Zinovkin Roman A., Chernyak Boris V., Krysko Dmitri V., Bachert Claus, Krysko Olga, Skulachev Vladimir P., Popova Ekaterina N. (2017) Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice. Biochimica et Biophysica Acta - Molecular Basis of Disease, >>

  13. Demyanenko I.A., Zakharova V.V., Ilyinskaya O.P., Vasilieva T.V., Fedorov A.V., Manskikh V.N., Zinovkin R.A., Pletjushkina O.Y., Chernyak B.V., Skulachev V.P., Popova E.N. (2017) Mitochondria-targeted antioxidant SkQ1 improves dermal wound healing in genetically diabetic mice. Oxidative Medicine and Cellular Longevity, >>

  14. Shagieva G., Domnina L., Makarevich O., Chernyak B., Skulachev V., Dugina V. (2017) Depletion of mitochondrial reactive oxygen species induces mesenchymal-to-epithelial transition in cervical cancer cells. Oncotarget, >>

  15. Fetisova Elena, Chernyak Boris, Korshunova Galina, Muntyan Maria, Skulachev Vladimir (2017) Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosis. Current Medicinal Chemistry, >>