Department of Protein Chemistry
Leader: Alexander A. Baykov
The Department was organized in 1965 and was first headed by Prof. A. B. Silaev, and later by Prof. S. M. Avaeva (1968-1989) and Prof. A. A. Baykov (1989-present). The Department includes three research groups headed by Dr. T.I Nazarova, Dr. G.A. Korshunova and Prof. A.A. Baykov. There are in total seven research fellows and one research assistant in the Department.
Research areas
The research efforts mainly fall in three principal areas: (a) structure, mechanism and role of the enzymes catalyzing inorganic polyphosphate hydrolysis, (b) interaction of ribosome with antibiotics, (c) chemical synthesis of the target-directed analogs of natural compounds.
(i) Studies on enzymes hydrolizing inorganic polyphosphates (A.A. Baykov)
(ii) Mechanism of ribosome functioning and design of new ribosome-directed antibiotics (G.A. Korshunova)
(ii) Investigation of bacterial protein complexes (T.I. Nazarova)
Research results
Our major achievements include determination of several tens of 3D structures of various derivatives of inorganic pyrophosphatases. Together with the results of detailed functional studies, these data allowed formulation of a most detailed mechanism of enzyme-catalyzed hydrolysis/synthesis of phosphoanhydride bond in pyrophosphate. This reaction mechanism involves two reaction pathways and five reaction intermediates. The key element of the mechanism is metal-assisted generation of a nucleophilic hydroxide ion via coordination of water molecule by two/three magnesium and transition metal ions. These studies also elucidated the role of quaternary structure in pyrophosphatase catalysis.
We also developed a range of analytical procedures to determine phosphate, pyrophosphate and various metal ions and procedures utilizing pyrophosphatase as an analytical reagent.
More recent achievements include design and synthesis of tylosin and erythromycin derivatives forming novel contacts with ribosomal tunnel walls, synthesis of new promising erythromycin analogs to overcome the resistance of microorganisms caused by methylation of the nucleotide residue A2058 in 23S rRNA, discoveries of a new evolutionary independent family (family II) of soluble pyrophosphatases, subfamily of pyrophosphatases containing regulatory CBS domain, Na+-transporting subfamily of membrane-bound bacterial pyrophosphatases, and identification of animal exopolyphosphatase.
The Department has been collaborating with the Institute of Crystallography and the Institute of Protein Research of the Russian Academy of Sciences, the Institute of Physico-Chemical Medicine of FMBA of the Russian Federation, the Institute for New Antibiotics, the University of Turku (Finland), the University of Illinois (U.S.A.) and the European Molecular Biology Laboratory (EMBL, Germany). Also involved in our work are researchers from the Chair of the Natural Compounds of the Department of Chemistry of the Moscow State University.
Grants and projects
The research was supported by grants from the Russian Foundation for Basic Research, the Federal Program “Leading Scientific Schools”, NIH Fogarty Program, Volkswagen Foundation. There are currently 3 grants from the Russian Foundation for Basic Research. The group of Dr. Korshunova is additionally supported in the framework of the “MegaProject for the practical use of the Skulachev ions” established by Mitotech Ltd.
Prizes
The scientific achievements of the Department were recognized by The State Prize of the USSR (S. M. Avaeva), VDNH medals (A. A. Baykov, C. M. Avaeva, V. N. Kasho) and All-Union Biochemical Society Prize (S. M. Avaeva). Department members has obtained 15 patents, including 5 international ones.
Educational activities
The Department is actively involved in the educational activity of the Chair of Natural Compounds and the Department of Bioengineering and Bioinformatics of the Moscow State University. During the last 5 years, members of the Department staff supervised 23 annual student projects, 10 Master and 5 PhD thesis works.
Research areas
The research efforts mainly fall in three principal areas: (a) structure, mechanism and role of the enzymes catalyzing inorganic polyphosphate hydrolysis, (b) interaction of ribosome with antibiotics, (c) chemical synthesis of the target-directed analogs of natural compounds.
(i) Studies on enzymes hydrolizing inorganic polyphosphates (A.A. Baykov)
(ii) Mechanism of ribosome functioning and design of new ribosome-directed antibiotics (G.A. Korshunova)
(ii) Investigation of bacterial protein complexes (T.I. Nazarova)
Research results
Our major achievements include determination of several tens of 3D structures of various derivatives of inorganic pyrophosphatases. Together with the results of detailed functional studies, these data allowed formulation of a most detailed mechanism of enzyme-catalyzed hydrolysis/synthesis of phosphoanhydride bond in pyrophosphate. This reaction mechanism involves two reaction pathways and five reaction intermediates. The key element of the mechanism is metal-assisted generation of a nucleophilic hydroxide ion via coordination of water molecule by two/three magnesium and transition metal ions. These studies also elucidated the role of quaternary structure in pyrophosphatase catalysis.
We also developed a range of analytical procedures to determine phosphate, pyrophosphate and various metal ions and procedures utilizing pyrophosphatase as an analytical reagent.
More recent achievements include design and synthesis of tylosin and erythromycin derivatives forming novel contacts with ribosomal tunnel walls, synthesis of new promising erythromycin analogs to overcome the resistance of microorganisms caused by methylation of the nucleotide residue A2058 in 23S rRNA, discoveries of a new evolutionary independent family (family II) of soluble pyrophosphatases, subfamily of pyrophosphatases containing regulatory CBS domain, Na+-transporting subfamily of membrane-bound bacterial pyrophosphatases, and identification of animal exopolyphosphatase.
The Department has been collaborating with the Institute of Crystallography and the Institute of Protein Research of the Russian Academy of Sciences, the Institute of Physico-Chemical Medicine of FMBA of the Russian Federation, the Institute for New Antibiotics, the University of Turku (Finland), the University of Illinois (U.S.A.) and the European Molecular Biology Laboratory (EMBL, Germany). Also involved in our work are researchers from the Chair of the Natural Compounds of the Department of Chemistry of the Moscow State University.
Grants and projects
The research was supported by grants from the Russian Foundation for Basic Research, the Federal Program “Leading Scientific Schools”, NIH Fogarty Program, Volkswagen Foundation. There are currently 3 grants from the Russian Foundation for Basic Research. The group of Dr. Korshunova is additionally supported in the framework of the “MegaProject for the practical use of the Skulachev ions” established by Mitotech Ltd.
Prizes
The scientific achievements of the Department were recognized by The State Prize of the USSR (S. M. Avaeva), VDNH medals (A. A. Baykov, C. M. Avaeva, V. N. Kasho) and All-Union Biochemical Society Prize (S. M. Avaeva). Department members has obtained 15 patents, including 5 international ones.
Educational activities
The Department is actively involved in the educational activity of the Chair of Natural Compounds and the Department of Bioengineering and Bioinformatics of the Moscow State University. During the last 5 years, members of the Department staff supervised 23 annual student projects, 10 Master and 5 PhD thesis works.
Articles
- Anashkin V.A., Bogachev A.V., Serebryakova M.V., Zavyalova E.G., Bertsova Y.V., Baykov A.A.(2025) Rapid kinetics of H+ transport by membrane pyrophosphatase: evidence for a direct-coupling mechanism. Biochemical and Biophysical Research Communications, >>
- Bezpalaya E., Kurilova S., Vorobyeva N., Rodina E.(2025) Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations. Life, >>
- Kurilova Svetlana, Vorobyeva Nataliya, Bezpalaya Ekaterina, Serebryakova Marina, Rodina Elena(2025) Human mitochondrial pyrophosphatase hPPA2: In vitro and in silico study of the factors affecting its function. Biochimica et Biophysica Acta - Proteins and Proteomics, >>
- Firsov Alexander M., Khailova Ljudmila S., Nazarov Pavel A., Ukraintsev Maxim, Kirsanov Roman S., Kovalchuk Sergei I., Lyamzaev Konstantin G., Panteleeva Alisa A., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2025) 2-Azido-4-nitrophenol is a light-sensitive antibacterial protonophore. Bioelectrochemistry, >>
- Antonenko Yuri N., Rudenko Alexander Y., Khailova Ljudmila S., Firsov Alexander M., Kirsanov Roman S., Lyamzaev Konstantin G., Panteleeva Alisa A., Popova Lyudmila B., Mariasina Sofia S., Kotova Elena A., Polshakov Vladimir I.(2025) Cyazofamid-dessulfonamide (CCIM) is an anionic uncoupler of oxidative phosphorylation in mitochondria and a protonophore on lipid membranes. Biochemical and Biophysical Research Communications, >>
- Galiullina R.A., Pigidanov A.A., Safronov G.G., Trusova S.V., Teplova A.D., Golyshev S.A., Serebryakova M.V., Kovaleva I.E., Litvinova A.V., Chichkova N.V., Vartapetian A.B.(2025) Retrograde transport of tobacco phytaspase is mediated by its partner, Tubby-like F-box protein 8. International Journal of Molecular Sciences, >>
- Sinichich Arseniy A., Krivonos Danil V., Baranova Anna A., Zhitlov Mikhail Y., Belozerova Olga A., Lushpa Vladislav A., Vvedensky Andrey V., Serebryakova Marina V., Kalganova Anastasia I., Kudzhaev Arsen M., Prokopenko Yuri A., Sinelnikova Sofia S., Truso(2025) Genome-Guided Metabolomic Profiling of Peptaibol-Producing Trichoderma. International Journal of Molecular Sciences, >>
- Kulikovsky Alexey, Yagmurov Eldar, Grigoreva Anastasiia, Popov Aleksandr, Severinov Konstantin, Nair Satish K., Lippens Guy, Serebryakova Marina, Borukhov Sergei, Dubiley Svetlana(2025) Bacillus subtilis Utilizes Decarboxylated S-Adenosylmethionine for the Biosynthesis of Tandem Aminopropylated Microcin C, a Potent Inhibitor of Bacterial Aspartyl-tRNA Synthetase. Journal of the American Chemical Society, >>
- Iakimov Nikolai P., Budynina Ekaterina M., Fomin Evgenii O., Egorova Alexandra A., Berkovich Anna K., Serebriakova Marina V., Grozdova Irina D., Melik-Nubarov Nikolay S.(2025) End-group analysis to characterize the ring-opening polymerization of propylene oxalate. Mendeleev Communications, >>
- Bogachev A.V., Anashkin V.A., Bertsova Y.V., Zavyalova E.G., Baykov A.A.(2024) Na+ Translocation Dominates over H+-Translocation in the Membrane Pyrophosphatase with Dual Transport Specificity. International Journal of Molecular Sciences, >>
- Bertsova Y.V., Serebryakova M.V., Anashkin V.A., Baykov A.A., Bogachev A.V.(2024) A redox-regulated, heterodimeric NADH:cinnamate reductase in Vibrio ruber. Biochemistry (Moscow), >>
- Anashkin V.A., Kirillova E.A., Orlov V.N., Baykov A.A.(2024) Specific mutations reverse regulatory effects of adenosine phosphates and increase their binding stoichiometry in CBS domain-containing pyrophosphatase. International Journal of Molecular Sciences, >>
- Bezpalaya Ekaterina Y., Matyuta Ilya O., Vorobyeva Natalia N., Kurilova Svetlana A., Oreshkov Sergey D., Minyaev Mikhail E., Boyko Konstantin M., Rodina Elena V.(2024) The crystal structure of yeast mitochondrial type pyrophosphatase provides a model to study pathological mutations in its human ortholog. Biochemical and Biophysical Research Communications, >>
- Kirsanov Roman S., Khailova Ljudmila S., Krasnov Vladimir S., Firsov Alexander M., Lyamzaev Konstantin G., Panteleeva Alisa A., Popova Lyudmila B., Nazarov Pavel A., Tashlitsky Vadim N., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Spontaneous reversal of small molecule-induced mitochondrial uncoupling: the case of anilinothiophenes. FEBS Journal, >>
- Khailova Ljudmila S., Kirsanov Roman S., Rokitskaya Tatyana I., Krasnov Vladimir S., Korshunova Galina A., Kotova Elena A., Yuri N.Antonenko(2024) Mitochondrial uncoupling caused by a wide variety of protonophores is differently sensitive to carboxyatractyloside in rat heart and liver mitochondria. Biochimica et Biophysica Acta - Bioenergetics, >>
- Kirsanov Roman S., Khailova Ljudmila S., Rokitskaya Tatyana I., Lyamzaev Konstantin G., Panteleeva Alisa A., Nazarov Pavel A., Firsov Alexander M., Iaubasarova Iliuza R., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, >>
- Rokitskaya Tatyana, Kirsanov Roman S., Khailova Ljudmila S., Panteleeva Alisa A., Lyamzaev Konstantin G., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Methylation of Phenyl Rings in Ester‐Stabilized Phosphorus Ylides Vastly Enhances Their Protonophoric Activity. Chembiochem : a European journal of chemical biology, >>
- Bertsova Y.V., Serebryakova M.V., Bogachev V.A., Baykov A.A., Bogachev A.V.(2024) Acrylate reductase of an anaerobic electron transport chain of the marine bacterium Shewanella woodyi. Biochemistry (Moscow), >>
- Galkina Svetlana I., Fedorova Natalia V., Golenkina Ekaterina A., Ksenofontov Alexander L., Serebryakova Marina V., Kordyukova Larisa V., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2024) Differential effects of angiotensin II and aldosterone on human neutrophil adhesion and concomitant secretion of proteins, free amino acids and reactive oxygen and nitrogen species. International Immunopharmacology, >>
- Medvedeva Maria V., Serebryakova Marina V., Matyushenko Alexander M., Nefedova Victoria V., Muronetz Vladimir I., Schmalhausen Elena V.(2024) Binding of glyceraldehyde-3-phosphate dehydrogenase to G-actin promotes the transnitrosylation reaction. Archives of Biochemistry and Biophysics, >>
- Mirzoeva N.Z., Pipiya S.O., Mokrushina Yu A., Serebryakova M.V., Grigorieva A.A., Dubiley S.A., Terekhov S.S., Smirnov I.V.(2024) Reconstruction of the Reaction of Andalusicin Lantibiotic Modification by Lanthionine Synthetase AncKC in a Heterologous Escherichia coli System. Acta Naturae (русскоязычная версия), >>
- Iakimov Nikolai P., Budynina Ekaterina M., Berkovich Anna K., Serebryakova Marina V., Platonov Vadim B., Fomin Evgenii O., Buyanovskaya Anastasia G., Mikheev Ivan V., Melik-Nubarov Nikolay S.(2024) Polymerization of six-membered propylene oxalate. European Polymer Journal, >>
- Мирзоева Н.З., Пипия С.О., Мокрушина Ю.А., Серебрякова М.В., Григорьева А.А., Дубилей С.А., Терехов С.С., Смирнов И.В.(2024) Реконструкция реакции модификации лантибиотика андалусицина лантионинсинтетазой AncKC в гетерологической системе Escherichia coli. Acta Naturae (русскоязычная версия), >>
- Zamakhov I.M., Anashkin V.A., Moiseenko A.V., Orlov V.N., Vorobyeva N.N., Sokolova O.S., Baykov A.A.(2023) The structure and nucleotide-binding characteristics of regulated cystathionine β-synthase domain-containing pyrophosphatase without one catalytic domain. International Journal of Molecular Sciences, >>
- Khailova Ljudmila S., Krasnov Vladimir S., Kirsanov Roman S., Popova Lyudmila B., Tashlitsky Vadim N., Kotova Elena A., Antonenko Yuri N.(2023) The transient character of mitochondrial uncoupling by the popular fungicide fluazinam is specific for liver. Archives of Biochemistry and Biophysics, >>
- Kirsanov Roman S., Khailova Ljudmila S., Rokitskaya Tatyana I., Iaubasarova Iliuza R., Nazarov Pavel A., Panteleeva Alisa A., Lyamzaev Konstantin G., Popova Lyudmila B., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2023) Ester-stabilized phosphorus ylides as protonophores on bilayer lipid membranes, mitochondria and chloroplasts. Bioelectrochemistry, >>
- Rokitskaya Tatyana I., Khailova Ljudmila S., Korshunova Galina A., Antonenko Yuri N.(2023) Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: Protonophoric vs leakage mechanisms. Biochimica et Biophysica Acta - Biomembranes, >>
- Zorova Ljubava D., Pevzner Irina B., Khailova Ljudmila S., Korshunova Galina A., Kovaleva Marina A., Kovalev Leonid I., Serebryakova Marina V., Silachev Denis N., Sudakov Roman V., Zorov Savva D., Rokitskaya Tatyana I., Popkov Vasily A., Plotnikov Egor Y.(2023) Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1. ANTIOXIDANTS, >>
- Baksheeva Viktoriia E., Tiulina Veronika V., Iomdina Elena N., Petrov Sergey Yu, Filippova Olga M., Kushnarevich Nina Yu, Suleiman Elena A., Eyraud Rémi, Devred François, Serebryakova Marina V., Shebardina Natalia G., Chistyakov Dmitry V., Senin Ivan I., (2023) Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma. International Journal of Molecular Sciences, >>
- Галкина С.И., Голенкина Е.А., Федорова Н.В., Ксенофонтов А.Л., Серебрякова М.В., Стадничук В.И., Баратова Л.А., Судьина Г.Ф.(2023) Действие дексаметазона на адгезию нейтрофилов человека и сопутствующую секрецию. Биохимия, >>
- Galkina Svetlana I., Golenkina Ekaterina A., Fedorova Natalia V., Ksenofontov Alexander L., Serebryakova Marina V., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2023) Effect of Dexamethasone on Adhesion of Human Neutrophils and Concomitant Secretion. Biochemistry (Moscow), >>
- Kuvarina A.E., Sukonnikov M.A., Timofeeva A.V., Serebryakova M.V., Baratova L.A., Buzurnyuk M.N., Golyshkin A.V., Georgieva M.L., Sadykova V.S.(2023) Uncovering the Effects of the Cultivation Condition on Different Forms of Peptaibol’s Emericellipsins Production from an Alkaliphilic Fungus, Emericellopsis alkalina. Fermentation, >>
- Barinova K.V., Serebryakova M.V., Melnikova A.K., Medvedeva M.V., Muronetz V.I., Schmalhausen E.V.(2023) Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal. Archives of Biochemistry and Biophysics, >>
- Teplova Anastasia D., Pigidanov Artemii A., Serebryakova Marina V., Golyshev Sergei A., Galiullina Raisa A., Chichkova Nina V., Vartapetian Andrey B.(2023) Phytaspase is Capable of Detaching the Endoplasmic Reticulum Retrieval Signal from Tobacco Calreticulin-3. International Journal of Molecular Sciences, >>
- Машковская А.В., Марьясина С.С., Серебрякова М.В., Рубцова М.П., Донцова О.А., Сергиев П.В.(2023) Проверка метилирования митохондриальной 12S рРНК предполагаемой метилтрансферазой METTL17. Acta Naturae (русскоязычная версия), >>
- Kordyukova Larisa V., Moiseenko Andrey V., Serebryakova Marina V., Shuklina Marina A., Sergeeva Maria V., Lioznov Dmitry A., Shanko Andrei V.(2023) Structural and Immunoreactivity Properties of the SARS-CoV-2 Spike Protein upon the Development of an Inactivated Vaccine. Viruses-Basel, >>
- Kuvarina A.E., Sukonnikov M.A., Rogozhin E.A., Serebryakova M.V., Timofeeva A.V., Georgieva M.L., Sadykova V.S.(2023) Formation of various antimicrobial peptide emericellipsin isoforms in Emericellopsis alkalina under different cultivation conditions. Applied Biochemistry and Microbiology, >>
- Куварина А.Е., Суконников М.А., Рогожин Е.А., Серебрякова М.В., Тимофеева А.В., Георгиева М.Л., Садыкова В.С.(2023) Образование различных изоформ антимикробных пептидов эмерициллипсинов у Emericellopsis alkalina при разных условиях культивирования. Прикладная биохимия и микробиология, >>
- Ivanenkov Yan A., Kukushkin Maxim E., Beloglazkina Anastasia A., Shafikov Radik R., Barashkin Alexander A., Ayginin Andrey A., Serebryakova Marina V., Majouga Alexander G., Skvortsov Dmitry A., Tafeenko Viktor A., Beloglazkina Elena K.(2023) Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity. Molecules, >>
- Malinen Anssi M., Anashkin Viktor A., Orlov Victor N., Bogachev Alexander V., Lahti Reijo, Baykov Alexander A.(2022) Pre-steady-state kinetics and solvent isotope effects support the “billiard-type” transport mechanism in Na+-translocating pyrophosphatase. Protein Science, >>
- Baykov Alexander A., Anashkin Viktor A., Malinen Anssi M., Bogachev Alexander V.(2022) The Mechanism of Energy Coupling in H+/Na+-Pumping Membrane Pyrophosphatase—Possibilities and Probabilities. International Journal of Molecular Sciences, >>
- Monakhova M.V., Kubareva Е.A., Kolesnikov K.K., Anashkin V.A., Kosaretskiy Е.M., Zvereva M.I., Romanova E.A., Friedhoff P., Oretskaya T.S., Zatsepin T.S.(2022) Reactive acrylamide-modified DNA traps for accurate cross-linking with cysteine residues in DNA–protein complexes using mismatch repair protein MutS as a model. Molecules, >>
- Krasnov Vladimir S., Kirsanov Roman S., Khailova Ljudmila S., Popova Lyudmila B., Lyamzaev Konstantin G., Firsov Alexander M., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2022) Alkyl esters of 7-hydroxycoumarin-3-carboxylic acid as potent tissue-specific uncouplers of oxidative phosphorylation: Involvement of ATP/ADP translocase in mitochondrial uncoupling. Archives of Biochemistry and Biophysics, >>
- Krasnov Vladimir S., Kirsanov Roman S., Khailova Ljudmila S., Firsov Alexander M., Nazarov Pavel A., Tashlitsky Vadim N., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2022) Alkyl esters of umbelliferone-4-acetic acid as protonophores in bilayer lipid membranes and ALDH2-dependent soft uncouplers in rat liver mitochondria. Bioelectrochemistry, >>
- Zorova Ljubava D., Demchenko Evgenia A., Korshunova Galina A., Tashlitsky Vadim N., Zorov Savva D., Andrianova Nadezda V., Popkov Vasily A., Babenko Valentina A., Pevzner Irina B., Silachev Denis N., Plotnikov Egor Y., Zorov Dmitry B.(2022) Is the mitochondrial membrane potential (∆ψ) correctly assessed? Intracellular and intramitochondrial modifications of the ∆Ψ probe, rhodamine 123. International Journal of Molecular Sciences, >>
- Rokitskaya Tatyana I., Aleksandrova Ekaterina V., Korshunova Galina A., Khailova Ljudmila S., Tashlitsky Vadim N., Luzhkov Victor B., Antonenko Yuri N.(2022) Membrane Permeability of Modified Butyltriphenylphosphonium Cations. Journal of Physical Chemistry B, >>
- Ilgova Ekaterina, Galkin Simon, Khrenova Maria, Serebryakova Marina, Gottikh Marina, Anisenko Andrey(2022) Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors. International Journal of Molecular Sciences, >>
- Ershova Natalia, Sheshukova Ekaterina, Kamarova Kamila, Arifulin Evgenii, Tashlitsky Vadim, Serebryakova Marina, Komarova Tatiana(2022) Nicotiana benthamiana Kunitz peptidase inhibitor-like protein involved in chloroplast-to-nucleus regulatory pathway in plant-virus interaction. Frontiers in plant science, >>
- Bertsova Y.V., Serebryakova M.V., Baykov A.A., Bogachev A.V.(2022) A novel, NADH-dependent acrylate reductase in Vibrio harveyi. Applied and Environmental Microbiology, >>
- Galkina Svetlana I., Fedorova Natalia V., Ksenofontov Alexander L., Golenkina Ekaterina A., Serebryakova Marina V., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2022) Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone Suppresses the Secretory Processes That Ensure the Invasion of Neutrophils into Tissues and Induce Inflammation. BIOMEDICINES, >>
- Dvoryakova Elena A., Klimova Maria A., Simonyan Tatiana R., Dombrovsky Ivan A., Serebryakova M., Tereshchenkova Valeriia F., Dunaevsky Yakov E., Belozersky Mikhail A., Filippova Irina Y., Elpidina Elena N.(2022) Recombinant Cathepsin L of Tribolium castaneum and Its Potential in the Hydrolysis of Immunogenic Gliadin Peptides. International Journal of Molecular Sciences, >>
- Pletnev Philipp I., Shulenina Olga, Evfratov Sergey, Treshin Vsevolod, Subach Maksim F., Serebryakova Marina V., Osterman Ilya A., Paleskava Alena, Bogdanov Alexey A., Dontsova Olga A., Konevega Andrey L., Sergiev Petr V.(2022) Ribosomal protein S18 acetyltransferase RimI is responsible for the acetylation of elongation factor Tu. Journal of Biological Chemistry, >>
- Galkina Svetlana I., Golenkina Ekaterina A., Serebryakova Marina V., Fedorova Natalia V., Ksenofontov Alexander L., Stadnichuk Vladimir I., Sud’ina Galina F.(2022) Ivermectin Affects Neutrophil-Induced Inflammation through Inhibition of Hydroxylysine but Stimulation of Cathepsin G and Phenylalanine Secretion. BIOMEDICINES, >>
- Schmalhausen E.V., Medvedeva M.V., Serebryakova M.V., Chagovets V.V., Muronetz V.I.(2022) Products of S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase: Relation between S-nitrosylation and oxidation. Biochimica et Biophysica Acta - General Subjects, >>
- Kuvarina Anastasia E., Rogozhin Eugene A., Sykonnikov Maxim A., Timofeeva Alla V., Serebryakova Marina V., Fedorova Natalia V., Kokaeva Lyudmila Y., Efimenko Tatiana A., Georgieva Marina L., Sadykova Vera S.(2022) Isolation and Characterization of a Novel Hydrophobin, Sa-HFB1, with Antifungal Activity from an Alkaliphilic Fungus, Sodiomyces alkalinus. Journal of Fungi, >>
- Yagmurov E., Gilep K., Serebryakova M., Wolf YI, Dubiley S., Severinov K.(2022) S51 Family Peptidases Provide Resistance to Peptidyl-Nucleotide Antibiotic McC. mBio, >>
- Kuvarina A.E., Gavryushina I.A., Sykonnikov M.A., Efimenko T.A., Markelova N.N., Bilanenko E.N., Bondarenko S.A., Kokaeva L.Y., Timofeeva A.V., Serebryakova M.V., Barashkova A.S., Rogozhin E.A., Georgieva M.L., Sadykova V.S.(2022) Exploring Peptaibol’s Profile, Antifungal, and Antitumor Activity of Emericellipsin A of Emericellopsis Species from Soda and Saline Soils. Molecules, >>
- Anashkin V.A., Baykov A.A.(2021) A lumenal loop associated with catalytic asymmetry in plant vacuolar H+-translocating pyrophosphatase. International Journal of Molecular Sciences, >>
- Anashkin Viktor A., Salminen Anu, Lahti Reijo, Baykov Alexander A.(2021) Tetrameric structure of cystathionine β-synthase domain-containing pyrophosphatase. FEBS open bio, >>
- Anashkin V.A., Malinen A.M., Bogachev A.V., Baykov A.A.(2021) Catalytic asymmetry in homodimeric H+‐pumping membrane pyrophosphatase demonstrated by non‐hydrolyzable pyrophosphate analogs. International Journal of Molecular Sciences, >>
- Baykov A.A., Anashkin V.A., Malinen A.M.(2021) Good-practice non-radioactive assays of inorganic pyrophosphatase activities. Molecules, >>
- Rokitskaya Tatyana I., Kotova Elena A., Luzhkov Victor B., Kirsanov Roman S., Aleksandrova Ekaterina V., Korshunova Galina A., Tashlitsky Vadim N., Antonenko Yuri N.(2021) Lipophilic ion aromaticity is not important for permeability across lipid membranes. Biochimica et Biophysica Acta - Biomembranes, >>
- Galkina Svetlana I., Golenkina Ekaterina A., Fedorova Natalia V., Ksenofontov Alexander L., Serebryakova Marina V., Arifulin Evgenii A., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2021) Inhibition of Neutrophil Secretion Upon Adhesion as a Basis for the Anti-Inflammatory Effect of the Tricyclic Antidepressant Imipramine. Frontiers in pharmacology, >>
- Bertsova Y.V., Serebryakova M.V., Baykov A.A., Bogachev A.V.(2021) The flavin transferase ApbE flavinylates the ferredoxin:NAD+-oxidoreductase Rnf required for N2 fixation in Azotobacter vinelandii. FEMS Microbiology Letters, >>
- Galkina Svetlana I., Fedorova Natalia V., Ksenofontov Alexander L., Serebryakova Marina V., Golenkina Ekaterina A., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2021) Neutrophil Adhesion and the Release of the Free Amino Acid Hydroxylysine. Cells, >>
- Teplova A.D., Serebryakova M.V., Galiullina R.A., Chichkova N.V., Vartapetian A.B.(2021) Identification of Phytaspase Interactors via the Proximity-Dependent Biotin-Based Identification Approach. International Journal of Molecular Sciences, >>
- Kordyukova Larisa V., Hu Bodan, Serebryakova Marina V., Veit Michael(2021) Differential Fatty Acylation Of Influenza A Virus Hemagglutinin Is Sensitive To Mutations In The Cholesterol Consensus Motive. Protein Science, >>
- Nůsková Hana, Serebryakova Marina V., Ferrer-Caelles Anna, Sachsenheimer Timo, Lüchtenborg Christian, Miller Aubry K., Brügger Britta, Kordyukova Larisa V., Teleman Aurelio A.(2021) Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins. Nature communications, >>
- Gadalla M.R., Morrison E., Serebryakova M.V., Han X., Wolff T., Freund C., Kordyukova L.V., Veit M.(2021) NS1-mediated upregulation of ZDHHC22 acyltransferase in Influenza A virus infected cells. Cellular Microbiology, >>
- Grigoreva Anastasiia, Andreeva Julia, Bikmetov Dmitry, Rusanova Anastasiia, Serebryakova Marina, Garcia Andrea Hernandez, Slonova Darya, Nair Satish K., Lippens Guy, Severinov Konstantin, Dubiley Svetlana(2021) Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis. iScience, >>
- Volpina Olga M., Koroev Dmitriy O., Serebryakova Marina V., Volkova Tatyana D., Kamynina Anna V., Bobkova Natalia V.(2021) Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models. Drug Development Research, >>
- Beloshistov RE, Dreizler K., Galiullina RA, Tuzhikov AI, Serebryakova MV, Reichardt S., Shaw J., Taliansky ME, Pfannstiel J., Chichkova NV, Stintzi A., Schaller A., Vartapetian AB(2018) Phytaspase-mediated precursor processing and maturation of the wound hormone systemin. New Phytologist, >>
- Fetisova Elena, Chernyak Boris, Korshunova Galina, Muntyan Maria, Skulachev Vladimir(2017) Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosis. Current Medicinal Chemistry, >>
- Metelev Mikhail, Osterman Ilya A., Ghilarov Dmitry, Khabibullina Nelli F., Yakimov Alexander, Shabalin Konstantin, Utkina Irina, Travin Dmitry Y., Komarova Ekaterina S., Serebryakova Marina, Artamonova Tatyana, Khodorkovskii Mikhail, Konevega Andrey L., S(2017) Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nature Chemical Biology, >>