Departments Department of Electron Microscopy

A. N. Belozersky Research Instituteof Physico-Chemical Biology MSU

  2. A. N. Belozersky Research Institute, MSU, Russia
  3. Departments and Laboratories
  4. Departments

Department of Electron Microscopy

Leader: Igor I. Kireev

The department was organized in 1965, led by prof. Yuri S. Chentsov. In 1991, prof. Vladimir Yu. Poliakov assumed a position of the department head. The main function of the Department is maintenance of Electron microscopy facility and providing assistance to the Institute researches in their experimental work that requires optical and electron microscopy.

Research areas

The department also conducts its own research in two directions: studies of general principles in structural-functional organization of genetic apparatus of eukaryotes and studies of mechanisms of cell motility. This research was supported by grants from RFBR, CRDF, INTAS, Soros’ Fund, grants from the President of Russian Federation to support young researchers and doctors of science (Alieva I., Kireev I., Sheval E.)

Research results

Since 2002 till 2012, the following important results were obtained:

The concept of a “modular” structure of eukaryotic chromosome has been proposed and experimentally confirmed, which postulates a hierarchy of macromolecular chromatin complexes – nucleomeres, chromomeres, chromonema within a mitotic and interphase chromosome. Such a “modular” principle of DNA compaction, on one hand, allows for local independent decondensation of DNA loci upon activation, while, on the other hand, limiting access to other DNA regions for site-specific DNA-binding proteins, such as DNA-methylases, TFs etc. (Zatsepina et al, 1983; Prusov et al, 1983, Sheval et al, 2002; Polyakov et al, 2006). It was also discovered that metaphase chromosome displays lateral differentiation where euchromatic transcriptionally-active and early-replicating chromosomal loci are preferentially located at the metaphase chromosome surface, while heterochromatin late-replicating loci occupy axial region (Kobliakova et al, 2005).

Studies of the dynamics of condensin association with chromosomes during mitotic and meiotic chromosome compaction, as well as under conditions of inducible changes in chromosome compaction level in vivo showed that condensins do not drive chromosome condensation and chromosomal axis formation (Kireeva et al., 2004), neither do they directly stabilize compact chromosome structure(Timirbulatova et al, 2002). Rather, they are involved in recruiting other architectural chromosome proteins. Fully-functional condensin complex is assembled sequentially on chromosomes during meiotic prophase with CAP-D2/pEg7 subunit being among the first to bind to chromosomes. In addition, individual condensin subunits display targeting to different non-chromatin nuclear domains, such as Cajal bodies and nucleoli (Uzbekov et al., 2003; Beenders et al., 2003).

The study of ultrastructure of replicating chromatin has demonstrated decondensation of chromomeres and chromonema in euchromatin decondence into 30-nm fibers and loose the ability to condense in response to divalent cations addition in vitro (Golyshev et al, 2007) while heterochromatin loci remain highly condensed during replication (Kireev et al, 2008).

The original concept of microtubules growth and shortening as a process of single-dimencional diffusion was introduced that allowed quantitative description of MT behavior. It was proposed that the role of centrosome is not limited to MT nucleation but mainly concerns spatial organization of free MT network through a set of stable Mts attached to the centrosome.

The study of in vitro cultivated human endotheliocytes expressing GFP-tagged cytoskeletal proteins revealed variations in dynamic interactions between fibrillar (MTs, actin filaments) and adhesive (focal contacts, VE-cadherin intercellular contacts) cytoskeletal structures in endotheliocytes under normal conditions and after administration of drugs compromising barrier function of endothelium (Birukova et al, 2004).

The study of plus-end capping proteins of CLASP family in mitosis showed that these proteins regulate MT dynamics in interphase while in mitosis they are involved in mitotic spindle organization and correct kinetochore orientation (Mimori-Kiyosue et al, 2005).

Prizes

Lomonosov Prize (V.Polyakov, O.Zatsepina), Shuvalov Prize (I.Alieva), IUPAB/UNESCO Prize (I.Alieva).

Education activities
Graduate and PhD students of the Department

Dudnik O.A.(1990-1993), Mukharyamova K.Sh.(1990-1993), Smirnova O., Pudenko A.S., Artyomenko E., Koblyakova Yu.V., Krokhina T.B. (1985-1986), Tkachova N. (1985-1986)., Abaimova T. (1985-1989), Gornung E.A. (1983-1987), Frolova E.A. (1984-1988), Vladimirskaya E. (1997-1998)., Grabeklis S.A., Abumuslimov S.S. (1988-1991), Grigoriev I., Zhukova N., Yamshanov A.N. (1994-1996)., Gozak P. (1982-1983), and others.

Lecture and practical courses
  • Cell Biology - Faculty of Bioinformatics ad Bioengineering (Vorobjev)
  • Cytogenetics (practical course) — Faculty of Bioinformatics ad Bioengineering (Alieva, Arifulin, Kurchashova, Golyshev, Kireev)
  • Electron Microscopy in Bionanotechnology (lecture and practical course) – Nanotechnology Educational program, Moscow State University (Kireev, Alieva, Golyshev, Kurchashova)
  • Introduction to Cell Biology —Faculty of Chemistry (Kireev)
  • Immunoelectron microscopy (practical course) – Faculty of Biology (Kireev)
Textbooks

Alieva I.,m Kireev I., Kurchashova S., Uzbekov R. «Methods of cell biology in cytogenetics» (Faculty of Bioinformatics ad Bioengineering). V.Polyakov and R.Uzbekov eds.
Laboratories

Articles

  • Guseva Ekaterina, Averina Olga, Isaev Sergey, Pletnev Philipp, Bragina Elizaveta, Permyakov Oleg, Buev Vitaly, Priymak Anastasia, Emelianova Mariia, Pshanichnaya Lizaveta, Romanov Evgeny, Novikova Svetlana E., Petriukov Kirill, Golovina Anna, Grigorieva O(2025) Positioning of sperm tail longitudinal columns depend on Nsun7, an RNA binding protein destabilizing elongated spermatid transcripts. RNA, >>
  • Guseva Ekaterina A., Averina Olga A., Buev Vitaly S., Bragina Elizaveta E., Permyakov Oleg A., Priymak Anastasia V., Emelianova Mariia A., Romanov Evgeny A., Grigoryeva Olga O., Manskikh Vasily N., Pletnev Philipp I., Sergiev Petr V.(2025) Testis-specific RNA methyltransferase NSUN7 contains a re-arranged catalytic site. Biochimie, >>
  • Chernykh Vyacheslav B., Bragina Elizaveta E., Kurilo Lyubov F., Pankratenkova Maria A., Kashintsova Anna A., Gabliya Mikhail Yu, Vinogradov Igor V., Vityazeva Irina I., Bogolyubov Sergey V., Spangenberg Victor E., Kolomiets Oxana L.(2025) Meiotic Arrest and Synaptonemal Complex failure in Infertile Men with Y Chromosome Microdeletions. Cytogenetic and Genome Research, >>
  • Sparber Peter, Ulas Evgeniia, Filatova Alexandra, Tatarskiy Eugene, Perelman Grigory, Makretskaya Nina, Nagaeva Elena, Kareva Maria, Frolova Elena, Kalinchenko Natalia, Tvorogova Anna V., Golyshev Sergey, Burakov Anton, Tabakov Vyacheslav, Lozier Ekaterin(2025) Out-of-frame Translation Rescues a Loss-of-function Variant in a Novel TBCE Phenotype. Journal of Clinical Endocrinology and Metabolism, >>
  • Galiullina R.A., Pigidanov A.A., Safronov G.G., Trusova S.V., Teplova A.D., Golyshev S.A., Serebryakova M.V., Kovaleva I.E., Litvinova A.V., Chichkova N.V., Vartapetian A.B.(2025) Retrograde transport of tobacco phytaspase is mediated by its partner, Tubby-like F-box protein 8. International Journal of Molecular Sciences, >>
  • Pozdyshev Denis V., Leisi Evgeniia V., Muronetz Vladimir I., Golyshev Sergei A., Kurochkina Lidia P.(2025) Cytotoxicity of α-synuclein amyloid fibrils generated with phage chaperonin OBP. Biochemical and Biophysical Research Communications, >>
  • Lyupina Yulia V., Adameyko Kim I., Zubarev Vasiliy M., Cherkasov Alexander V., Ryabova Alina V., Mikhailov Kirill V., Golyshev Sergey A., Burakov Anton V., Finoshin Alexander D., Erokhov Pavel A., Sabirov Marat S., Zhurakovskaya Anna I., Ziganshin Rustam (2025) The divergent intron-containing actin in sponge morphogenetic processes. NAR Genomics and Bioinformatics, >>
  • Leisi Evgeniia V., Zyurkalova Darya V., Dzhus Uliana F., Nikulin Alexey D., Golyshev Sergei A., Muronetz Vladimir I., Kurochkina Lidia P.(2025) Interaction of phage chaperonin OBP domains with amyloidogenic proteins. Archives of Biochemistry and Biophysics, >>
  • Казаков Е.П., Киреев И.И., Голышев С.А.(2025) Методы селективного мечения молекул и субклеточных структур для криоэлектронной томографии. Биохимия, >>
  • Kazakov Evgeny P., Kireev Igor I., Golyshev Sergei A.(2025) Techniques for Selective Labeling of Molecules and Subcellular Structures for Cryo-Electron Tomography. Biochemistry (Moscow), >>
  • Efremova Maria V., Wiedwald Ulf, Sigmund Felix, Bodea Silviu-Vasile, Ohldag Hendrik, Feggeler Thomas, Meckenstock Ralf, Panzl Lorenz N., Francke Jeroen, Beer Irina, Ivleva Natalia P., Alieva Irina B., Garanina Anastasiia S., Semkina Alevtina S., Curdt Fra(2025) Genetically Controlled Iron Oxide Biomineralization in Encapsulin Nanocompartments for Magnetic Manipulation of a Mammalian Cell Line. Advanced Functional Materials, >>
  • Парфентьева О.И., Даял А.А., Гебреселасе Б.А., Гиоева Ф.К., Алиева И.Б., Минин А.А.(2025) Роль виментина в образовании нейритов. Russian Journal of Developmental Biology, >>
  • Исаев Н.К., Генрихс Е.Е., Стельмашук Е.В.(2025) Влияние дезоксиглюкозы на культивированные глиальные клетки коры головного мозга крыс при стимуляции ЛПС. Клеточные технологии в биологии и медицине, >>
  • Valyaeva A.A., Tikhomirova M.A., Feng J., Zharikova A.A., Potashnikova D.M., Musinova Y.R., Mironov A.A., Vassetzky Y.S., Sheval E.V.(2025) Compensatory reactions of B cells in response to chronic HIV‐1 Tat exposure. Journal of Cellular Physiology, >>
  • Тюлина В.В., Лаврушкина С.В., Довгий А.И., Сенин И.И.(2025) Защитное действие кондиционированной среды мезенхимных стволовых клеток костного мозга на роговицу кроликов с нарушением рефлекса моргания. Бюллетень экспериментальной биологии и медицины, >>
  • Tikhomirova M.A., Zharikova A.A., Musinova Y.R., Sheval E.V.(2025) Immunocytochemical detection of proteins within cellular structures inaccessible to specific antibodies. Histochemistry and Cell Biology, >>
  • MA Adrianov, Bobrov M., Mamedov I., Manskikh V., Sheval EV, Rachkova AA, Shelechova AM, Eldarov CM, Averina OA, Vyssokikh MY(2025) A set of microRNAs are differentially expressed in cachexic naked mole rat colony members after chronic heavy burden under normoxia. Biochimie, >>
  • Bragina Elizaveta, Kurchashova Svetlana, Suhomlinova Marina, Gasanova Tatiana, Ermolaeva Svetlana, Sorokina Tatyana, Kirs Eva, Arifulin Evgeniy, Solovova Olga, Ryzhkova Oxana, Khayat Sabina, Andreeva Marina, Chernykh Vyacheslav(2024) Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia. Frontiers in genetics, >>
  • Kyian T., Borovikov A., Anisimova I., Ryzhkova O., Maria Bulakh M., Bragina E., Avakyan M., Demchenko A., Zabnenkova V., Kovalev V., Bukhonin A., Kondratyeva E., Kutsev S1(2024) Expanding the Genotypic and Phenotypic Spectrum of OFD1-Related Conditions: Three More Cases. Genes, >>
  • Стрельникова В.А., Овсянников Д.Ю., Пушков А.А., Айрапетян М.И., Брагина Е.Е., Булынко С.А., Воронкова А.Ю., Гитинов Ш.А., Горев В.В., Григориадис Н.К., Гутырчик Т.А., Деева Е.В., Жилина С.В., Карпенко М.А., Колганова Н.И., Кондакова О.Б., Лаберко Е.Л., М(2024) Первичная цилиарная дискинезия у детей: клиническая, лабораторно-инструментальная и генетическая характеристика. Педиатрия. Consilium Medicum, >>
  • Гамидова1, Макарова Н.П., Смольникова В.Ю., Лобанова Н.Н., Кулакова Е.В., Брагина Е.Е.(2024) Особенности хроматинового статуса сперматозоидов при отборе по мембранному дзета-потенциалу в программах лечения бесплодия методами ВРТ. Медицинский оппонент, >>
  • Сорокина Т.М., Брагина Е.Е., Курило Л.Ф., Соловова О.А., Штаут М.И., Седова А.О., Черных В.Б.(2024) Семейный случай мужского бесплодия с тотальной астенозооспермией, обусловленной структурными нарушениями в аксонеме жгутика сперматозоидов. Андрология и генитальная хирургия, >>
  • Kondratyeva E.I., Avdeev S.N., Kyian T.A., Merzhoeva Z.M., Karpova O.A., Bragina E.E., Ryzhkova O.P., Popova V.M., Starinova M.A., Chernykh V.B.(2024) Comparative characteristics of patients with primary ciliary dyskinesia with or without Kartagener’s syndrome. Пульмонология, >>
  • Tikhomirova M.A., Kuzmenko O.L., Arifulin E.A., Shirokova O.M., Musinova Y.R., Sheval E.V.(2024) The nucleocapsid (N) proteins of different human coronaviruses demonstrate a variable capacity to induce the formation of cytoplasmic condensates. International Journal of Molecular Sciences, >>
  • Arifulin E.A., Sorokin D.V., Anoshina N.A., Kuznetsova M.A., Valyaeva A.A., Potashnikova D.M., Omelchenko D.O., Schubert V., Kolesnikova T.D., Sheval E.V.(2024) Global nuclear reorganization during heterochromatin replication in the giant-genome plant Nigella damascena L. Plant Journal, >>
  • Arifulin E.A., Sheval E.V.(2024) Non-canonical localization of cardiac troponins: expanding functions or causing pathologies?. International Journal of Molecular Sciences, >>
  • Atabekova Anastasia K., Lazareva Ekaterina A., Lezzhov Alexander A., Golyshev Sergei A., Skulachev Boris I., Morozov Sergey Y., Solovyev Andrey G.(2024) Defense Responses Induced by Viral Movement Protein and Its Nuclear Localization Modulate Virus Cell-to-Cell Transport. Plants, >>
  • Golyshev Sergei A., Lyupina Yulia V., Kravchuk Oksana I., Mikhailov Kirill V., Gornostaev Nicolay G., Burakov Anton V.(2024) Transient Interphase Microtubules Appear in Differentiating Sponge Cells. Cells, >>
  • Малышев И.В., Реунов Д.Г., Чхало Н.И., Торопов М.Н., Пестов А.Е., Полковников В.Н., Чернышев А.К., Плешков Р.С., Казаков Е.П., Лаврушкина С.В., Голышев С.А., Поспелов А.Д., Широкова О.М.(2024) Корреляционная экстремальная ультрафиолетовая, ультрафиолетовая и оптическая микроскопия на базе зеркального микроскопа с аксиальной томографией. Журнал технической физики, >>
  • Dayal A.A., Parfenteva O.I., Wang H., Gebreselase B.A., Gyoeva F.K., Alieva I.B., Minin A.A.(2024) Vimentin Intermediate Filaments Maintain Membrane Potential of Mitochondria in Growing Neurites. Biology, издательство MDPI. Biology, >>
  • Dayal Alexander A., Parfenteva Olga I., Wang Huiying, Shakhov Anton S., Alieva Irina B., Minin Alexander A.(2024) VIMENTIN AND DESMIN INTERMEDIATE FILAMENTS MAINTAIN MITOCHONDRIAL MEMBRANE POTENTIAL. Biochemistry (Moscow), >>
  • Алиева И.Б., Шахов A.С., Даял А.А., Чуркина А.С., Парфентьева О.И., Минин А.А.(2024) Уникальная роль виментина в семействе белков промежуточных филаментов. Биохимия, >>
  • Ryzhikova Olga V., Churkina Aleksandra S., Sedenkova Kseniya N., Savchenkova Daiana V., Shakhov Anton S., Lavrushkina Svetlana V., Grishin Yuri K., Zefirov Nikolay A., Zefirova Olga N., Gracheva Yulia A., Milaeva Elena R., Alieva Irina B., Averina Elena B(2024) Mono- and bis(steroids) containing a cyclooctane core: Synthesis, antiproliferative activity, and action on cell cytoskeleton microtubules. Archiv der Pharmazie, >>
  • Alieva Irina B., Shakhov Anton S., Dayal Alexander A., Churkina Aleksandra S., Parfenteva Olga I., Minin Alexander A.(2024) Unique Role of Vimentin in the Intermediate Filament Proteins Family. Biochemistry (Moscow), >>
  • Genrikhs E.E., Shedenkova M.O., Voronkov D.N., Isaev N.K., Stelmashook E.V.(2024) Activation of Microglia and Astroglia in Unilateral Focal Traumatic Brain Injury in Rats. Bulletin of Experimental Biology and Medicine, >>
  • Генрихс Е.Е., Шеденкова М.О., Воронков Д.Н., Исаев Н.К., Стельмашук Е.В.(2024) Активация микроглии и астроглии при односторонней фокальной черепно-мозговой травме крыс. Бюллетень экспериментальной биологии и медицины, >>
  • Goswami Sakshi, Isaev Nickolay K., Salmina Alla B., Rana Suresh Vir Singh, Illarioshkin Sergey N., Verma Yeshvandra(2024) Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy. Brain Disorders, >>
  • Стельмашук Е.В., Будагова Т.Ю., Генрихс Е.Е., Исаев Н.К.(2024) Внеклеточный ацидоз, цистеин и глутатион усиливают токсическое действие ионов меди в культурах зернистых нейронов мозжечка. Бюллетень экспериментальной биологии и медицины, >>
  • Wang Wenzhu, Zhao Jingyu, Li Zihan, Kang Xiaoyu, Li Ting, Isaev Nickolay K., Smirnova Elena A., Shen Hui, Liu Lixu, Yu Yan(2024) L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury. Biomedicine and Pharmacotherapy, >>
  • Isaev Nickolay K., Genrikhs Elizaveta E., Stelmashook Elena V.(2024) Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer's disease. Reviews in the Neurosciences, >>
  • Валяева А.А., Шеваль Е.В.(2024) Неспецифические взаимодействия в регуляции транскрипции и организации транскрипционных конденсатов. Биохимия, >>
  • Shcherbakova Anastasia, Utkina Marina, Valyaeva Anna, Pachuashvili Nano, Bondarenko Ekaterina, Urusova Liliya, Popov Sergey, Mokrysheva Natalya(2024) Factors Affecting Cell Viability during the Enzymatic Dissociation of Human Endocrine Tumor Tissues. Biology, >>
  • Valyaeva A.A., Sheval E.V.(2024) Nonspecific interactions in transcription regulation and organization of transcriptional condensates. Biochemistry (Moscow), >>
  • Velichko Artem K., Kovina Anastasia P., Luzhin Artem V., Petrova Nadezhda V., Deriglazov Dmitry A., Kazakov Eugene P., Kireev Igor I., Razin Sergey V., Kantidze Omar L.(2024) Treacle’s ability to form liquid phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair. eLife, >>
  • Volkova V.O., Sheval E.V., Lipina T.V.(2024) Telocyte networks: Integrating histogenetic processes in health and disease. Russian Journal of Developmental Biology, >>
  • Кошелев Д.В., Черкасов В.А., Медведева Н.Е., Шеваль Е.В., Рыбаков В.А., Старичков Е.В., Старичкова Д.В., Никитин Е.А., Виноградов А.А., Иопек В.А.(2024) О встречах редких видов птиц в Твери и Тверской области в 2023 году. Русский орнитологический журнал, >>
  • Shmakova A., Hugot C., Kozhevnikova Y., Schwager (Karpukhina) A., Tsimailo I., Gérard L., Boutboul D., Oksenhendler E., Szewczyk-Roszczenko O., Roszczenko P., Buzun K., Sheval E.V., Germini D., Vassetzky Y.(2024) Chronic HIV‐1 Tat action induces HLA‐DR downregulation in B cells: A mechanism for lymphoma immune escape in people living with HIV. Journal of Medical Virology, >>
  • Задубенко Д., Локшин В., Зыкова Г., Брагина Е., Айташева З., Задубенко Р., Голиченков В.(2023) Потенциал внедрения электронно-микроскопического исследования сперматозоидов человека в практику отделения вспомогательных репродуктивных технологий. Репродуктивная медицина, >>
  • Khayat S.Sh, Bragina E.E., Kurilo L.F., Chernykh V.B.(2023) Genetic and spermatological aspects of acephalic sperm syndrome. Андрология и генитальная хирургия, >>
  • Bragina Elizaveta, Sorokina Tatyana, Chogovadze Avtandil, Shevchenko Yulia, Chernykh Vyacheslav, Barkhatova Olga, Rakovskaya Irina(2023) Detection and evaluation of different morphological forms of Mycoplasma hominis in human semen. Asian Journal of Andrology, >>
  • Nikolaeva E.D., Ovsyannikov D.Yu, Strel’nikova V.A., Polyakov D.P., Tronza T.V., Karpova O.A., Fatkhullina I.R., Bragina \cyrchar\CYRE E., Shchagina O.A., Starinova M.A., Krasovskiy S.\cyrchar\CYRA, Kyian T.A., Zhekaite E.K.(2023) Characteristics of patients with primary ciliary dyskinesia. Пульмонология, >>
  • Chernykh VyacheslavB, Sedova AnnaO, Shtaut MariaI, Bragina ElizavetaE, Sorokina TatyanaM, Shmarina GalinaV, Andreeva MarinaV, Kurilo LyubovF, Krasovskiy StanislavA, Polyakov AleksanderV(2023) Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis. Asian Journal of Andrology, >>
  • Kamarova Kamila A., Ershova Natalia M., Sheshukova Ekaterina V., Arifulin Eugene A., Ovsiannikova Natalia L., Antimonova Alexandra A., Kudriashov Andrei A., Komarova Tatiana V.(2023) Nicotiana benthamiana Class 1 Reversibly Glycosylated Polypeptides Suppress Tobacco Mosaic Virus Infection. International Journal of Molecular Sciences, >>
  • Atabekova Anastasia K., Golyshev Sergei A., Lezzhov Alexander A., Skulachev Boris I., Moiseenko Andrey V., Yastrebova Daria M., Andrianova Nadezda V., Solovyev Ilya D., Savitsky Alexander P., Morozov Sergey Y., Solovyev Andrey G.(2023) Fine Structure of Plasmodesmata-Associated Membrane Bodies Formed by Viral Movement Protein. Plants, >>
  • Chergintsev Denis A., Solovieva Anna D., Atabekova Anastasia K., Lezzhov Alexander A., Golyshev Sergei A., Morozov Sergey Y., Solovyev Andrey G.(2023) Properties of Plant Virus Protein Encoded by the 5′-Proximal Gene of Tetra-Cistron Movement Block. International Journal of Molecular Sciences, >>
  • Teplova Anastasia D., Pigidanov Artemii A., Serebryakova Marina V., Golyshev Sergei A., Galiullina Raisa A., Chichkova Nina V., Vartapetian Andrey B.(2023) Phytaspase is Capable of Detaching the Endoplasmic Reticulum Retrieval Signal from Tobacco Calreticulin-3. International Journal of Molecular Sciences, >>
  • Голышев С.А., Казаков Е.П., Киреев И.И., Реунов Д.Г., Малышев И.В.(2023) Микроскопия мягкого рентгеновского диапазона в клеточной биологии: современное состояние, вклад и перспективы. Acta Naturae (англоязычная версия), >>
  • Maslakova A.A., Golyshev S.A., Potashnikova D.M., Moisenovich A.M., Orlovsky I.V., Smirnova O.V., Rubtsov M.A.(2023) SERPINA1 long transcripts produce non-secretory alpha1-antitrypsin isoform: In vitro translation in living cells. International Journal of Biological Macromolecules, >>
  • Shedenkova Margarita O., Stelmashook Elena V., Golyshev Sergey A., Genrikhs Elizaveta E., Isaev Nickolay K.(2023) Extracellular Alkalosis Reduces the Neurotoxicity of Zinc Ions in Cultured Cerebellar Granule Neurons. Biological Trace Element Research, >>
  • Курчашова С.Ю., Гасанова Т.В.(2023) Ламины - "кирпичики" ядерной архитектуры. Потенциал. Химия. Биология. Медицина, >>
  • Pasko V.I., Churkina A.S., Shakhov A.S., Kotlobay A.A., Alieva I.B.(2023) Modeling of Neurodegenerative Diseases: ‘Stepby Step’ and ‘Network’ Organizationof the Complexes of Model Systems. International Journal of Molecular Sciences, >>
  • Shakhov A.S., Churkina A.S., Kotlobay A.A., Alieva I.B.(2023) The Endothelial Centrosome: Specific Features and Functional Significance for Endothelial Cell Activity. International Journal of Molecular Sciences, >>
  • Стельмашук Е.В., Александрова О.П., Генрихс Е.Е., Верма E., Салмина А.Б., Исаев Н.К.(2023) Ионы меди снижают токсическое действие азида натрия и липополисахарида на культивированные зернистые нейроны мозжечка. Анналы клинической и экспериментальной неврологии, >>
  • Isaev Nickolay K., Stelmashook Elena V., Genrikhs Elizaveta E., Onishchenko Galina E.(2023) Interaction Between Mitophagy, Cadmium and Zinc. Journal of Trace Elements in Medicine and Biology, >>
  • Isaev Nickolay K., Genrikhs Elizaveta E., Stelmashook Elena V.(2023) Antioxidant Thymoquinone and Its Potential in the Treatment of Neurological Diseases. ANTIOXIDANTS, >>
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  • Gulov Alexey N., Bragina Yelizaveta E.(2022) Cryopreservation effects on drone sperm Apis mellifera L. morphometric parameters and ultrastructure. Ветеринария, зоотехния и биотехнология, >>
  • Ershova Natalia, Sheshukova Ekaterina, Kamarova Kamila, Arifulin Evgenii, Tashlitsky Vadim, Serebryakova Marina, Komarova Tatiana(2022) Nicotiana benthamiana Kunitz peptidase inhibitor-like protein involved in chloroplast-to-nucleus regulatory pathway in plant-virus interaction. Frontiers in plant science, >>
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  • Sosnovskaya Sophie, Zakirov Amir N., Ryumina Ekaterina D., Kharybina Ekaterina, Golyshev Sergei A., Strelkova Olga S., Zhironkina Oxana A., Moiseenko Andrei, Orekhov Anton, Kireev Igor I.(2022) Imaging replicative domains in ultrastructurally preserved chromatin by electron tomography. Jove-Journal of Visualized Experiments, >>
  • Maslakova A.A., Didych D.A., Golyshev S.A., Katrukha I.A., Viushkov V.S., Zamalutdinov A.V., Potashnikova D.M., Rubtsov M.A., Smirnova O.V., Orlovsky I.V.(2022) Towards unveiling the nature of short SERPINA1 transcripts: Avoiding the main ORF control to translate alpha1-antitrypsin C-terminal peptides. International Journal of Biological Macromolecules, >>
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  • Shakhov Anton S., Alieva Irina B.(2022) The “Third Violin” in the Cytoskeleton Orchestra—The Role of Intermediate Filaments in the Endothelial Cell’s Life. BIOMEDICINES, >>
  • Aleksandra Taran, Shuvalova Lilia, Lavrushkina Svetlana, Bogomazova Alexandra, Lagarkova Maria, Alieva Irina(2022) Microtubule plus-end dynamics visualization in Huntington's disease model based on human primary skin fibroblasts. Jove-Journal of Visualized Experiments, >>
  • Stelmashook E.V., Isaev N.K., Genrikhs E.E., Khaspekov L.G.(2022) The Effect of Modulation of Na+/K+-АТPase Activity on the Viability of Cerebellar Granule Cells Exposed to Oxidative Stress in vitro. Human Physiology, >>
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  • Stelmashook Elena V., Alexandrova Olga P., Genrikhs Elizaveta E., Novikova Svetlana V., Salmina Alla B., Isaev Nickolay K.(2022) Effect of zinc and copper ions on cadmium-induced toxicity in rat cultured cortical neurons. Journal of Trace Elements in Medicine and Biology, >>
  • Стельмашук Е.В., Капкаева М.Р., Розанова Н.А., Александрова О.П., Генрихс Е.Е., Обмолов В.В., Новикова С.В., Исаев Н.К.(2022) Влияние индуктора нейровоспаления на компоненты нейроваскулярной единицы головного мозга in vitro. Российский физиологический журнал им. И.М.Сеченова, >>
  • Евдокимов В.В., Исаев Н.К., Туровецкий В.Б.(2022) Влияние факторов различной природы на фертильность эякулята in vitro. Андрология генитальная хирургия, >>
  • Shedenkova M.O., Stelmashook E.V., Isaev N.K.(2022) Toxic Effect of Zinc Ions Is Accompanied by Acidification of the Cytoplasm in Cultured Rat Cerebellar Granule Neurons. Bulletin of Experimental Biology and Medicine, >>
  • Epremyan Khoren K., Goleva Tatyana N., Rogov Anton G., Lavrushkina Svetlana V., Zinovkin Roman A., Zvyagilskaya Renata A.(2022) The First Yarrowia lipolytica Yeast Models Expressing Hepatitis B Virus X Protein: Changes in Mitochondrial Morphology and Functions. Microorganisms, >>
  • Sheval E.V.(2022) Comment on Piña et al. Ten Approaches That Improve Immunostaining: A Review of the Latest Advances for the Optimization of Immunofluorescence. International Journal of Molecular Sciences, >>
  • Sorokina T.M., Bragina E.E., Sorokina E.A., Kurilo L.F., Shtaut M.I., Sedova A.O., Chernykh V.B.(2021) Evaluation and comparative analysis of sperm characteristics in men before and after vaccination with Sputnik V (Gam-COVID-Vac). Андрология и генитальная хирургия, >>
  • Сорокина Т.М., Брагина Е.Е., Сорокина Е.А., Седова А.О., Штаут М.И., Курило Л.Ф., Черных В.Б.(2021) Влияние перенесенной инфекции COVID-19на спермиологические показатели мужчин с нарушением фертильности. Андрология и генитальная хирургия, >>
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  • Kolomiets O.L., Bragina E.E., Kashintsova A.A., Spangenberg V.E., Nikulina L.A., Korolev Yu N., Mikhailik L.V.(2021) Study of Sertoli cells and spermatogenic cells in rats with experimentally induced metabolic syndrome and after balneophysiotherapy. Андрология и генитальная хирургия, >>
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  • Galkina Svetlana I., Golenkina Ekaterina A., Fedorova Natalia V., Ksenofontov Alexander L., Serebryakova Marina V., Arifulin Evgenii A., Stadnichuk Vladimir I., Baratova Ludmila A., Sud’ina Galina F.(2021) Inhibition of Neutrophil Secretion Upon Adhesion as a Basis for the Anti-Inflammatory Effect of the Tricyclic Antidepressant Imipramine. Frontiers in pharmacology, >>
  • Golenkina Ekaterina A., Galkina Svetlana I., Dolinnaya Nina G., Arifulin Evgenii A., Romanova Yulia M., Sud’ina Galina F.(2021) Synthetic Hexanucleotides as a Tool to Overcome Excessive Neutrophil Activation Caused by CpG-Containing Oligonucleotides. PATHOGENS, >>
  • Skuredina A.A., Tychinina A.S., Le-Deygen I.M., Golyshev S.A., Belogurova N.G., Kudruashova E.V.(2021) The formation of quasi-regular polymeric network of cross-linked sulfobutyl ether derivative of β-cyclodextrin synthesized with moxifloxacin as a template. Reactive and Functional Polymers, >>
  • Dugina VB, Shagieva GS, Shakhov AS, Alieva IB(2021) The Features of the Cytoplasmic Actins: Cytoskeletal Structures and Functional Activities. Journal of Clinical and Cellular Immunology, >>
  • Dugina V.B., Shagieva G.S., Shakhov A.S., Alieva I.B.(2021) The Cytoplasmic Actins in the Regulation of Endothelial Cell Function. International Journal of Molecular Sciences, >>
  • Genrikhs E.E., Kapkaeva M.R., Stelmashook E.V., Isaev N.K., Khaspekov L.G.(2021) Toxic Effect of Streptozotocin on Cultured Mouse Hippocampal Neurons. Bulletin of Experimental Biology and Medicine, >>
  • Генрихс Е.Е., Капкаева М.Р., Стельмашук Е.В., Исаев Н.К., Хаспеков Л.Г.(2021) Токсическое действие стрептозоцина на культивированные нейроны гиппокампа мышей. Бюллетень экспериментальной биологии и медицины, >>
  • Genrikhs E.E., Stelmashook E.V., Rogozin P.D., Novikova S.V., Aleksandrova O.P., Sobolev V.B., Skrebitsky V.G., Isaev N.K.(2021) SkQR1 Reduces Neurologic Deficit Caused by Rat Brain Compression Ischemia. Bulletin of Experimental Biology and Medicine, >>
  • Siozopoulou V., Khmelevskiy A., Rodlauer-Kriegl A., de Caluwe T., Churov A., Valyaeva A., Bruyen L.De, Wener R., Specenier P., Cuvelier C., Thienpont M., Richtig E., Pauwels P.(2021) 24P Using real-world evidence data and machine learning to identify molecular biomarkers for patient response to immune checkpoint inhibitors in metastatic melanoma. Annals of Oncology, >>
  • Dugina V., Shagieva G., Novikova M., Lavrushkina S., Sokova O., Kireev I., Kopnin P.(2021) Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line. Molecules, >>
  • Ovsiannikova Natalia L., Lavrushkina Svetlana V., Ivanova Anastasia V., Mazina Ludmila M., Zhironkina Oxana A., Kireev Igor I.(2021) Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease. Biochemistry (Moscow), >>
  • Овсянникова Н.Л., Лаврушкина С.В., Иванова А.В., Мазина Л.М., Жиронкина О.А., Киреев И.И.(2021) Ламин A как определяющий фактор механических свойств ядра в норме и при патологии. Биохимия, >>
  • Овсянникова Н.Л., Иванова А.В., Лаврушкина С.В., Киреев И.И.(2021) Влияние накопления преламина A на миграционную и пролиферативную активность опухолевых клеток за счет действия лопинавира и батимастата. Успехи молекулярной онкологии, >>
  • Kolmogorov Vasilii, Erofeev Alexandr, Woodcock Emily, Efremov Yuri, Iakovlev Aleksei, Savin Nikita, Alova Anna, Lavrushkina Svetlana, Kireev Igor, Prelovskaya Alexandra, Sviderskaya Elena, Scaini Denis, Klyachko Natalia L., Timashev Peter S., Takahashi Ya(2021) Mapping mechanical properties of living cells at nanoscale using intrinsic nanopipette-sample force interaction. Nanoscale, >>
  • Kolmogorov Vasilii, Vaneev Alexander, Efremov Yuri M., Savin Nikita, Iakovlev Aleksei, Alova Anna, Lavrushkina Svetlana, Erofeev Alexander, Gorelkin Petr, Klyachko Natalia, Kireev Igor, Majouga Alexander, Novak Pavel, Korchev Yuri E.(2021) Studying the Local Young's Modulus of PC-3 Cells Via Scanning Ion-Conductance Microscopy. Biophysical Journal, >>
  • Akbay B., Germini D., Bissenbaev A.K., Musinova Y.R., Sheval E.V., Vassetzky Y., Dokudovskaya S.(2021) HIV-1 Tat activates Akt/mTORC1 pathway and AICDA expression by downregulating its transcriptional inhibitors in B cells. International Journal of Molecular Sciences, >>
  • Velichko Artem, Ovsiannikova Natalia, Petrova Nadezhda, Luzhin Artem, Panyavina Maria, Gavrikov Alexey, Mishin Alexander, Kireev Igor, Razin Sergey, Kantidze Omar(2021) Treacle and TOPBP1 control replication stress response in the nucleolus. Journal of Cell Biology, >>
  • Ulianov Sergey V., Velichko Artem K., Magnitov Mikhail D., Luzhin Artem V., Golov Arkadiy K., Ovsyannikova Natalia, Kireev Igor I., Gavrikov Alexey S., Mishin Alexander S., Garaev Azat K., Tyakht Alexander V., Gavrilov Alexey A., Kantidze Omar L., Razin S(2021) Suppression of liquid–liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells. Nucleic Acids Research, >>
  • Tikhomirova M.A., Sheval E.V.(2021) Formation of biomolecular condensates: regulation of embryogenesis at the cellular level. Russian Journal of Developmental Biology, >>
  • Тихомирова М.А., Шеваль Е.В.(2021) Формирование биомолекулярных конденсатов: регуляция эмбриогенеза на клеточном уровне. Онтогенез, >>
  • Vorobjeva N.V., Galkin I.I., Pletjushkina O.Y., Golyshev S.A., Zinovkin R.A., Prikhodko A.S., Pinegin V.B., Kondratenko I.V., Pinegin B.V., Chernyak B.V.(2020) Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils. Biochimica et Biophysica Acta - Molecular Basis of Disease, >>
  • El-Amine R., Germini D., Zakharova V.V., Tsfasman T., Sheval E.V., Louzada R.A.N, Dupuy C., Bilhou-Nabera C., Hamade A., Najjar F., Oksenhendler E., Lipinski M., Chernyak B.V., Vassetzky Y.S.(2018) HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production. Redox Biology, >>

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