Department of Nucleic Acids Chemistry
Leader: Marina B. Gottikh
The division was founded in 1966 and up to 1999 it was headed by Prof. Z.A. Shabarova. Since 1999 the division has been headed by Prof. T.S. Oretskaya. The main researchers in the devision are: Prof. M.B. Gottikh, Prof. E.A. Kubareva, PhD V.L. Drutza, PhD E.A. Romanova, PhD M.G. Ivanovskaya.
Research areas
(i) The design and synthesis of oligonucleotides with chemically active groups for preparation of NA fragments derivatives and affine modification of proteins were developed
(ii) New DNA reagents were characterized as instruments in studying the molecular structure of nucleic acid - protein complexes
(iii) The structural and functional characteristics of complexes between DNA and a bifunctional enzyme C5-cytosine DNA-methyltransferase SsoII (M.SsoII) were studied
(iv) The protein activity regulation strategy was designed by using external signal
(v) Physico-chemical and biological properties of thymidine glycol containing DNA were investigated
(vi) The features of protein - DNA recognition in the DNA mismatch repair system were determined
(vii) DNA methyltransferases: methylation of the damaged DNA, inhibition, mechanism were investigated
(viii) A new technique of detecting non-canonical base pairs in DNA was developed
(ix) The study of the retroviral integration mechanism and the search for HIV-1 integrase inhibitors were carried out
(x) The structure and function of E.coli RNA polymerase were studied
Educational activities
Educational activities in forms of lectures, practical trainings and seminars are provided for students and post-graduates of Moscow State University particularly from Faculty of Chemistry and Faculty of Bioengineering and Bioinformatics.
During the last 3 years Department researchers supervised 10 PhD theses and 12 graduate works that were successfully defended.
Lecture courses
Professor Gottikh M.B – course “Chemistry of Nucleic Acids” for 4-th year students of Faculty of Chemistry.
Professor Oretskaya T.S. – course “Chemistry of mono- and dicarbohydrates” for 3-th year students of Faculty of Chemistry
Research areas
- Synthesis and development of new types of modified DNA and RNA fragments including those containing modified chemically active groups in any position of the sugar-phosphate backbone. The use of synthetic NA reagents capable of reacting spontaneously with nucleophylic amino acids in the NA - protein complex in order to define the structural basics for specificity in the complex as well as mechanisms of action of regulatory proteins and gene expression modulation.
- The development of the fotoregulation of the DNA-binding enzymes activity by changing the configuration of azobenzene derivatives. This approach changes the local structure within the protein or else limits the active center accessibility for the substrate.
- The study of the influence of point lesions in the DNA on: the double helix structure, the binding with functional proteins and enzymes, on biological methylation of nucleic acids.
- The determination of molecular structure of the key proteins in the DNA mismatch repair system (MMR) and the study of the regulation mechanisms that guide the complex activity.
- The development of general approaches towards the analysis of the “molecular anatomy” and the functioning of various RNA-protein complexes. The study of the role of a new type of regulators – short untranslated RNAs (6S RNAs). These RNAs are capable of a transcription initiation by the means of a direct binding to bacterial RNA polymerase. The study of supramolecular RNA-protein complexes and of a newly discovered RNAse P analog PRORP1 from Arabidopsis thaliana. PRORP1 is involved in tRNA processing in mitochondria and chloroplasts in plants.
- The study of the HIV-1 integrase that is one the main HIV enzymes. The study involves the analysis of the integrase interaction with viral and cellular DNA, the characteristics of the structural peculiarities of the viral DNA that correspond to the binding specificity with integrase, the study of the kinetics of the integrase catalyzed reactions. The study of various new HIV-1 integrase inhibitors and their mechanism of action. The development of a system for directed DNA integration by the means of a direct modification of HIV-1 integrase as well as of an integrase from prototype foamy virus so that these enzymes would specifically recognize a certain sequence within human genome.
(i) The design and synthesis of oligonucleotides with chemically active groups for preparation of NA fragments derivatives and affine modification of proteins were developed
(ii) New DNA reagents were characterized as instruments in studying the molecular structure of nucleic acid - protein complexes
(iii) The structural and functional characteristics of complexes between DNA and a bifunctional enzyme C5-cytosine DNA-methyltransferase SsoII (M.SsoII) were studied
(iv) The protein activity regulation strategy was designed by using external signal
(v) Physico-chemical and biological properties of thymidine glycol containing DNA were investigated
(vi) The features of protein - DNA recognition in the DNA mismatch repair system were determined
(vii) DNA methyltransferases: methylation of the damaged DNA, inhibition, mechanism were investigated
(viii) A new technique of detecting non-canonical base pairs in DNA was developed
(ix) The study of the retroviral integration mechanism and the search for HIV-1 integrase inhibitors were carried out
(x) The structure and function of E.coli RNA polymerase were studied
Educational activities
Educational activities in forms of lectures, practical trainings and seminars are provided for students and post-graduates of Moscow State University particularly from Faculty of Chemistry and Faculty of Bioengineering and Bioinformatics.
During the last 3 years Department researchers supervised 10 PhD theses and 12 graduate works that were successfully defended.
Lecture courses
Professor Gottikh M.B – course “Chemistry of Nucleic Acids” for 4-th year students of Faculty of Chemistry.
Professor Oretskaya T.S. – course “Chemistry of mono- and dicarbohydrates” for 3-th year students of Faculty of Chemistry
Articles
- Трефилов В.С., Линдин Е.Ю., Монахова М.В., Кисиль О.В., Вирясов М.Б., Орецкая Т.С., Кубарева Е.А.(2025) Инструментальные подходы к обнаружению и количественному определению сурфактина. Биоорганическая химия, >>
- Trefilov V.S., Lindin E.Yu, Monakhova M.V., Kisil O.V., Viryasov M.B., Oretskaya T.S., Kubareva E.A.(2025) Instrumental Approaches to the Detection and Quantification of Surfactin. Russian Journal of Bioorganic Chemistry, >>
- Savitskaya V.Yu, Novoselov K.A., Dolinnaya N.G., Monakhova M.V., Snyga V.G., Diatlova E.A., Peskovatskova E.S., Golyshev V.M., Kitaeva M.I., Eroshenko D.A., Zvereva M.I., Zharkov D.O., Kubareva E.A.(2025) Position-dependent effects of AP sites within an hTERT promoter G-quadruplex scaffold on quadruplex stability and repair activity of the APE1 enzyme. International Journal of Molecular Sciences, >>
- Bai Petr A., Solovjev Anton M., Kubareva Elena A., Kurzeev Sergey A., Sakharov Ivan Yu(2025) Chemiluminescent heterogeneous and homogeneous-heterogeneous assays for determination of nicking endonuclease activity. Analytical Biochemistry, >>
- Agapkina Y.Y., Ponomareva T.Y., Vdovina M.V., Ziganshin R.H., Rozina A.A., Anisenko A.N., Gottikh M.B.(2025) New Cellular Partners of HIV-1 Integrase and their Role in Viral Replication. Doklady Biochemistry and Biophysics, >>
- Жердева В.В., Рассомахина Н.В., Юркова А.Ю., Монахова М.В., Гук Е.А., Апухтина У.А., Малошенок Л.Г.(2025) Снижение экспрессии генов цитоскелета в опухолевых клетках при лентивирусной трансдукции. Молекулярная генетика, микробиология и вирусология, >>
- Королева О.Н., Кузьмина Н.В., Толстова А.П., Дубровин Е.В., Друца В.Л.(2024) Влияние добавки С- и N-концевого полигистидинового тега на агрегацию белка NEP вируса гриппа A. Биохимия, >>
- Koroleva Olga N., Kuzmina Natalya V., Tolstova Anna P., Dubrovin Evgeniy V., Drutsa Valerii L.(2024) Effect of C- and N-Terminal Polyhistidine Tags on Aggregation of Influenza A Virus Nuclear Export Protein. Biochemistry (Moscow), >>
- Дубровин Е.В., Королева О.Н., Кузьмина Н.В., Друца В.Л.(2024) Исследование агрегатов белка ядерного экспорта вируса гриппа А с помощью атомно-силовой микроскопии. Наноиндустрия, >>
- Koroleva Olga N., Kuzmina Natalia V., Dubrovin Evgeniy V., Drutsa Valeriy L.(2024) Atomic force microscopy of spherical intermediates on the pathway to fibril formation of influenza A virus nuclear export protein. Microscopy Research and Technique, >>
- Kikhai Tatiana F., Agapkina Yulia Yu, Prikazchikova Tatiana A., Vdovina Maria V., Shekhtman Sofia P., Fomicheva Sofia V., Korolev Sergey P., Marina B.Gottikh(2024) Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration. Biochemistry (Moscow), >>
- Korolev Sergey P., Shulepova Aleksandra A., Anisenko Andrey N., Galkin Simon O., Alexandrova Liudmila A., Jasko Maxim V., Matyugina Elena S., Novikov Mikhail S., Khandazhinskaya Anastasiya L., Kochetkov Sergey N., Gottikh Marina B.(2024) Dual-Reporter SARS-CoV-2 Replicon for Screening Viral Polymerase Inhibitors. Biochemistry (Moscow), >>
- Petushkov I., Elkina D., Burenina O., Kubareva E., Kulbachinskiy A.(2024) Key interactions of RNA polymerase with 6S RNA and secondary channel factors during pRNA synthesis. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, >>
- Линдин Е.Ю., Трефилов В.С., Буренина О.Ю., Зверева М.Э., Кубарева Е.А.(2024) Малая некодирующая 6S РНК в регуляции биосинтеза сурфактина клетками Bacillus subtilis. Биотехнология, >>
- Trefilov V.S., Labanov V.A., Khrenova M.G., Panova T.V., Rodin V.A., Savitskaya V.Y., Kubareva E.A., Zvereva M.I.(2024) Genomic characterization of Bacillus subtilis PY79 and NCIB 3610 as potential producers of surfactin. Applied Biochemistry and Microbiology, >>
- Sergeev A.V., Loiko A.G., Genatullina A.I., Petrov A.S., Kubareva E.A., Dolinnaya N.G., Gromova E.S.(2024) Crosstalk between G-quadruplexes and Dnmt3a-mediated methylation of c-MYC oncogene promoter. International Journal of Molecular Sciences, >>
- Molchanova Marina V., Ikonnikova Viktoria A., Anisenko Andrey N., Gottikh Marina B., Baranov Mikhail S., Mikhaylov Andrey A.(2024) The cycloaddition reaction of benzothiazolium ylides with α-cyanocinnamamides: the synthesis of structural analogs of inhibitors of HIV-1 post-integrational repair. Chemistry of Heterocyclic Compounds, >>
- Anisenko Andrey N., Nefedova Anastasiia A., Kireev Igor I., Gottikh Marina B.(2024) Post-Integrational DNA Repair of HIV-1 Is Associated with Activation of the DNA-PK and ATM Cellular Protein Kinases and Phosphorylation of Their Targets. Biochemistry (Moscow), >>
- Nikitenko Ekaterina D., Borisenko Ilya E., Anisenko Andrey N., Vortsepneva Elena V.(2024) Transcriptomic sequence dataset of a potential new model species for studying biomineralization Onchidoris muricata (Nudibranchia, Gastropoda, Mollusca). Data in Brief, >>
- Nikitenko E.D., Anisenko A.N., Vortsepneva E.V.(2024) Regeneration in the dorids exemplified by Onchidoris muricata (Gastropoda, Nudibranchia). RUTHENICA: РУССКИЙ МАЛАКОЛОГИЧЕСКИЙ ЖУРНАЛ, >>
- Kikhai T., Agapkina Y., Silkina M., Prikazchikova T., Gottikh M.(2024) The cellular SFPQ protein as a positive factor in the HIV-1 integration. Biochimie, >>
- Karpov A.S., Elkina D.A., Oretskaya T.S., Kubareva E.A.(2023) Bacterial аdaptation mechanisms to stress conditions with small non-coding RNAs рarticipation (a review). Russian Journal of Bioorganic Chemistry, >>
- Карпов А.С., Елкина Д.А., Орецкая Т.С., Кубарева Е.А.(2023) Механизмы адаптации бактерий к стрессовым условиям посредством малых некодирующих РНК. Биоорганическая химия, >>
- Anisenko Andrey, Galkin Simon, Mikhaylov Andrey A., Khrenova Maria G., Agapkina Yulia, Korolev Sergey, Garkul Lidia, Shirokova Vasilissa, Ikonnikova Viktoria A., Korlyukov Alexander, Dorovatovskii Pavel, Baranov Mikhail, Gottikh Marina(2023) KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair. International Journal of Molecular Sciences, >>
- Arutyunyan A.F., Kostyukov A.A., Korolev S.P., Gottikh M.B., Kaluzhny D.N., Susova O.Yu, Zhuze A.L.(2023) DNA Sequence-Specific Ligands. 19. Synthesis, Spectral Properties, Virological and Biochemical Studies of DB3(n) Fluorescent Dimeric Trisbenzimidazoles. Molecular Biology, >>
- Khomutov M.A., Salikhov A.I., Mitkevich V.A., Tunitskaya V.L., Smirnova O.A., Korolev S.P., Chizhov A.O., Gottikh M.B., Kochetkov S.N., Khomutov A.R.(2023) C-Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects. Biomolecules, >>
- Арутюнян А.Ф., Костюков А.А., Королев С.П., Готтих М.Б., Сусова О.Ю., Калюжный Д.Н., Жузе А.Л.(2023) Лиганды, специфичные к определенным последовательностям ДНК. XIX. Синтез, спектральные зарактеристики, вирусологические и биохимические исследования флуоресцентных симметричных димерных трисбензимидазолов DB3(n). Молекулярная биология. Молекулярная биология, >>
- Arutyunyan Albert F., Kostyukov Alexey A., Lushpa Vladislav A., Mineev Konstantin S., Korolev Sergey P., Gottikh Marina B., Klimova Regina R., Kushch Alla A., Kalabina Kseniya V., Susova Olga Yu, Zhuze Alexei L.(2023) DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n). Medicinal Chemistry Research, >>
- Panova V.V., Dolinnaya N.G., Novoselov K.A., Savitskaya V.Y., Chernykh I.S., Kubareva E.A., Alexeevski A.V., Zvereva M.I.(2023) Conserved G-quadruplex-forming sequences in mammalian TERT promoters and their effect on mutation frequency. Life, >>
- Savitskaya V.Y., Strekalovskikh V.V., Snyga V.G., Monakhova M.V., Arutyunyan A.M., Dolinnaya N.G., Kubareva E.A.(2023) pilE G-QuadruplexIs recognized and preferentially bound but not processed by the MutL endonuclease from Neisseria gonorrhoeae mismatch repair pathway. International Journal of Molecular Sciences, >>
- Savitskaya V.Y., Dolinnaya N.G., Strekalovskikh V.V., Peskovatskova E.S., Snyga V.G., Trefilov V.S., Monakhova M.V., Kubareva E.A.(2023) Bioinformatics analysis of global diversity in Meningococcal vaccine antigens over the past 10 Years: vaccine efficacy prognosis. Medical Sciences, >>
- Трефилов В.С., Лабанов В.А., Хренова М.Г., Панова Т.В., Родин В.А., Савицкая В.Ю., Кубарева Е.А., Зверева М.Э.(2023) Геномная характеристика бактерий Bacillus subtilis PY79 И NCIB 3610 как потенциальных продуцентов сурфактина. Биотехнология, >>
- Pavlova A.V., Dolinnaya N.G., Zvereva M.I., Kubareva E.A., Monakhova M.V.(2023) New DNA plasmid model for studying DNA mismatch repair response to the G4 structure. International Journal of Molecular Sciences, >>
- Кисиль О.В., Трефилов В.С., Садыкова В.С., Зверева М.Э., Кубарева Е.А.(2023) Сурфактин: биологическая активность и возможность применения в сельском хозяйстве. Прикладная биохимия и микробиология, >>
- Kisil O.V., Trefilov V.S., Sadykova V.S., Zvereva M.E., Kubareva E.A.(2023) Surfactin: its biological activity and possibilityof application in agriculture. Applied Biochemistry and Microbiology, >>
- Anisenko Andrey, Nefedova Anastasiia, Agapkina Yulia, Gottikh Marina(2023) Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair. International Journal of Molecular Sciences, >>
- Monakhova M.V., Kubareva Е.A., Kolesnikov K.K., Anashkin V.A., Kosaretskiy Е.M., Zvereva M.I., Romanova E.A., Friedhoff P., Oretskaya T.S., Zatsepin T.S.(2022) Reactive acrylamide-modified DNA traps for accurate cross-linking with cysteine residues in DNA–protein complexes using mismatch repair protein MutS as a model. Molecules, >>
- Burenina O.Y., Elkina D.A., Ovcharenko A., Bannikova V.A., Schlüter M.A.C, Oretskaya T.S., Hartmann R.K., Kubareva E.A.(2022) Involvement of E. coli 6S RNA in oxidative stress response. International Journal of Molecular Sciences, >>
- Hyvönen M.T., Smirnova O.A., Mitkevich V.A., Tunitskaya V.L., Karpov D.S., Khomutov M.R., Korolev S.P., Pietilä M., Ivanov A.V., Gottikh M.B., Vepsäläinen J., Alhonen L., Makarov A.A., Kochetkov S.N., Wallace H.M., Keinänen T.A., Khomutov A.R.(2022) Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions. International Journal of Molecular Sciences, >>
- Savitskaya V.Yu, Monakhova M.V., Iakushkina I.V., Borovikova I.I., Kubareva E.A.(2022) Neisseria gonorrhoeae: DNA repair systems and their role in pathogenesis. Biochemistry (Moscow), >>
- Савицкая В.Ю., Монахова М.В., Якушкина Ю.В., Боровикова И.И., Кубарева Е.А.(2022) Бактерия Neisseria gonorrhoeae: системы репарации ДНК и их роль в патогенезе. Биохимия, >>
- Loiko A.G., Sergeev A.V., Genatullina A.I., Monakhova M.V., Kubareva E.A., Dolinnaya N.G., Gromova E.S.(2022) Impact of G-quadruplex structures on methylation of model substrates by DNA methyltransferase Dnmt3a. International Journal of Molecular Sciences, >>
- Pavlova A.V., Savitskaya V.Yu, Dolinnaya N.G., Monakhova M.V., Litvinova A.V., Kubareva E.A., Zvereva M.I.(2022) G-quadruplex formed by the promoter region of the hTERT gene: structure-driven effects on DNA mismatch repair functions. BIOMEDICINES, >>
- Anna Rozina, Anisenko Andrey, Kikhai Tatiana, Silkina Maria, Gottikh Marina(2022) Сomplex Relationships between HIV-1 Integrase and Its Cellular Partners. International Journal of Molecular Sciences, >>
- Shadrina Olga, Garanina Irina, Anisenko Andrey, Kireev Igor, Gottikh Marina(2022) Transcriptome analysis of HEK 293T cells revealed different significance of the depletion of DNA-dependent protein kinase subunits, Ku70, Ku80, and DNA-PKcs. Biochimie, >>
- Gudkov Alexander, Shirokorad Valery, Kashintsev Kirill, Sokov Dmitriy, Nikitin Daniil, Anisenko Andrey, Borisov Nicolas, Sekacheva Marina, Gaifullin Nurshat, Garazha Andrew, Suntsova Maria, Koroleva Elena, Buzdin Anton, Sorokin Maksim(2022) Gene Expression-Based Signature Can Predict Sorafenib Response in Kidney Cancer. Frontiers in Molecular Biosciences, >>
- Ilgova Ekaterina, Galkin Simon, Khrenova Maria, Serebryakova Marina, Gottikh Marina, Anisenko Andrey(2022) Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors. International Journal of Molecular Sciences, >>
- Галкин С.О., Анисенко А.Н., Шадрина О.А., Готтих М.Б.(2022) ГЕННО-ИНЖЕНЕРНЫЕ СИСТЕМЫ ДЛЯ ИЗУЧЕНИЯ ВИРУСНЫХ ПАТОГЕНОВ ЧЕЛОВЕКА ИЗ СЕМЕЙСТВА Coronaviridae. Молекулярная биология, >>
- Galkin S.O., Anisenko A.N., Shadrina O.A., Gottikh M.B.(2022) Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Family. Molecular Biology, >>
- Шадрина О.А., Кихай Т.Ф., Агапкина Ю.Ю., Готтих М.Б.(2022) Белки SFPQ, NONO и длинная некодирующая РНК NEAT1: функции в клетке и в жизненном цикле ВИЧ-1. Молекулярная биология, >>
- Shadrina O.A., Kikhai T.F., Agapkina Yu Yu, Gottikh M.B.(2022) SFPQ and NONO Proteins and Long Non-Coding NEAT1 RNA: Cellular Functions and Role in the HIV-1 Life Cycle. Molecular Biology, >>
- Abrosimova L.A., Kuznetsov N.A., Astafurova N.A., Samsonova A.R., Karpov A.S., Perevyazova T.A., Oretskaya T.S., Fedorova O.S., Kubareva E.A.(2021) Kinetic аnalysis of the interaction of nicking endonuclease BspD6I with DNA. Biomolecules, >>
- Perry S.A., Kubareva E.A., Monakhova M.V., Trikin R.M., Kosaretskiy E.M., Romanova E.A., Metelev V.G., Friedhoff P., Oretskaya T.S.(2021) DNA with a 2-pyridyldithio group at the C2' atom: a promising tool for the crosslinking of the MutS protein preserving its functional activity. Russian Journal of Bioorganic Chemistry, >>
- Burenina O.Y., Oretskaya T.S., Kubareva E.A.(2021) Detection of small products of transcription from 6S RNA (pRNA) by “mirror-like” northern blot hybridization. Russian Journal of Bioorganic Chemistry, >>
- Буренина О.Ю., Орецкая Т.С., Кубарева Е.А.(2021) Детекция малых пРНК – продуктов транскрипции 6S РНК – с помощью нозерн-блот-гибридизации в "зеркальном" варианте. Биоорганическая химия, >>
- Перри С.А., Кубарева Е.А., Монахова М.В., Трикин Р.М., Косарецкий Е.М., Романова Е.А., Метелев В.Г., Фридхофф П., Орецкая Т.С.(2021) ДНК с 2-пиридилдитиогруппой при С2'-атоме – перспективные инструменты для фиксации белка MutS с сохранением его функциональной активности. Биоорганическая химия, >>
- Metelev V.G., Oretskaya T.S.(2021) Modified Oligonucleotides: New Structures, New Properties, and New Spheres of Application. Russian Journal of Bioorganic Chemistry, >>
- Метелев В.Г., Орецкая Т.С.(2021) Модифицированные олигонуклеотиды: новые структуры, новые свойства, новые области применения. Биоорганическая химия, >>
- Kapitonova М.А., Shadrina O.A., Korolev S.P., Gottikh M.B.(2021) Main Approaches to Controlled Protein Degradation in the Cell. Molecular Biology, >>
- Капитонова М.А., Шадрина О.А., Королев С.П., Готтих М.Б.(2021) ОСНОВНЫЕ ПОДХОДЫ К КОНТРОЛИРУЕМОЙ ДЕГРАДАЦИИ БЕЛКОВ В КЛЕТКЕ. Молекулярная биология, >>
- Панова В.В., Тулаева Е.Р., Новоселов К.А., Кубарева Е.А., Зверева М.Э., Алексеевский А.В.(2021) Биоинформатический анализ соматических мутаций в контексте образования G-квадруплексов в промоторе гена TERT и в других онкогенах. Успехи молекулярной онкологии, >>
- Павлова А.В., Савицкая В.Ю., Монахова М.В., Зверева М.Э., Кубарева Е.А.(2021) Необычный характер взаимодействия ключевых белков системы репарации «мисматчей» с фрагментом промотора гена TERT, содержащим G-квадруплексы. Успехи молекулярной онкологии, >>
- Павлова А.В., Писарев Э.К., Монахова М.В., Кубарева Е.А., Зверева М.Э.(2021) Взаимосвязь возникновения драйверных мутаций с наличием G-квадруплексных структур в ДНК при канцерогенезе на примере промоторной области гена TERT. Успехи молекулярной онкологии, >>
- Pavlova A.V., Kubareva E.A., Monakhova M.V., Zvereva M.I., Dolinnaya N.G.(2021) Impact of G-quadruplexes on the regulation of genome integrity, DNA damage and repair. Biomolecules, >>
- Monakhova M.V., Milakina M.A., Savitskaya V.Yu, Romanova E.A., Rao D.N., Kubareva E.A.(2021) MutL protein from the Neisseria gonorrhoeae mismatch repair system: interaction with ATP and DNA. Molecular Biology, >>
- Монахова М.В., Милакина М.А., Савицкая В.Ю., Романова Е.А., Rao D.N., Кубарева Е.А.(2021) Белок MutL из системы репарации мисматчей бактерии Neisseria gonorrhoeae: взаимодействие с ATP и ДНК. Молекулярная биология, >>
- Anna Rozina, Anisenko Andrey, Galkin Simon, Gottikh Marina(2021) XL-MS for novel HIV-1 integrase partners detection. Protein Science, >>
- Galkin Simon, Anisenko Andrey, Shadrina Olga, Gottikh Marina(2021) Luciferase-based SARS-CoV-2 Replicon System for Studying Viral Replication and Discontinuous Transcription. Protein Science, >>
- Ilgova Ekaterina, Galkin Simon, Anisenko Andrey, Gottikh Marina(2021) Rational Screening for Inhibitors of the HIV Integrase-Ku70 (XRCC6) Interaction. Protein Science, >>
- Anisenko Andrey, Shadrina Olga, Garanina Irina, Gottikh Marina(2021) Transcriptome dataset of HEK293T cells depleted of one of the subunits of the DNA-PK complex: Ku70, Ku80 or DNA-PKcs. Data in Brief, >>
- Kikhai T., Agapkina Y., Shadrina O., Gottikh M.(2021) The role of human SFPQ protein in HIV1 replication. FEBS open bio, >>
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