Departments Department of RNA Structure and Functions

A. N. Belozersky Research Instituteof Physico-Chemical Biology MSU

  2. A. N. Belozersky Research Institute, MSU, Russia
  3. Departments and Laboratories
  4. Departments

Department of RNA Structure and Functions

Leader: Olga A. Dontsova

Research areas
(i) Studying of the translation

Protein synthesis is one of the most important process in cell. Ribosome is a huge complicated complex consisting of RNA and proteins. Ribosome prepares the protein synthesis from the amino acids using the information coded in matrix RNA. Bacterial ribosome consists from two subunits – small (30S) and big (50S).

One of the tasks is to study the process of translation initiation and the role of initiation codons. mRNA includes 5’-noncoding region with Shine-Dalgarno sequence, which responsible for the right ribosome position. So, different variants of the Shine-Dalgarno sequence influence on the regulation of the protein translation. Furthermore, translation is impossible without the initiation factors, the role of them is not describe in full.

Other problem is the detection and research the rRNA and protein modifications during translation. It is known the big variety of various additional chemical functional groups which join to nucleotides and amino acids by specific modification in the cell. In bacteria very often separate enzyme modifys one position, so for cell it is necessary to synthesize a set of enzymes. Why is it so important for cell? What is the role of each modification? In ribosomal RNA there are more than thirty modified nucleotides, the most part is methylated. The majority of methylated nucleotides are in proximity from functionally significant ribosome centers and influence on the efficiency and accuracy of translation stages. Our interest is a concrete role of some modified nucleotides of rRNA and ribosomal proteins. For example, protein S6 contains two and more glutamic acids on the S-end, which considerably strengthen its total negative charge. Work is directed on finding-out how and during what moment and why for it occurs.

The third direction of the work in our group is studying of the antibiotics acting on the ribosome (3). Antibiotics suppress the bacteria growth or leads to the death. The majority of antibiotics block the protein synthesis in bacteria. It is known that bacteria are capable to adapt to the pernicious action of such substances, getting to them stability. The given phenomenon causes the requirement of search all new and new antibiotics. It is necessary to investigate mechanisms of their action for improvement of their antibacterial activity.

(ii) Studying of the telomerase in various organisms

Eukaryotic chromosomes end with special DNA-protein structures which are called telomeres. After being replicated telomere DNA shortens; this process leads to the genome instability and causes senescence. Telomerase is a unique enzyme, which is capable of synthesizing telomeric DNA on the basis of its own RNA subunit; the main function of the complex is to maintain telomere length. In humans telomerase is highly active in the cells which possess unlimited proliferative potential – they are known to be germ and stem cells. However, in most of the human cells telomerase activity is downregulated. Study of the telomere biogenesis allows to propose the connection between the low activity of the enzyme and aging of an organism. On the other hand telomerase upregulation is a key step for a cell to transform into a cancer one. It makes the complex an attractive target for the development of anti-cancer therapies.

The research in our laboratory focuses on several directions. We study structure and function of telomerase using yeast as a model system. We are especially interested in the Est3 protein, which is known to be important participant of S.cerevisiae telomerase complex. Its novel functions were shown in our lab, in particular, the ability to unbind specifically DNA-RNA hetero duplexes. This work enables to hypothesize that the Est3 plays an important role in providing processivity of the telomerase. Study of the Est3 regulation, its interaction with the telomeric DNA and telomerase will add much to our understanding of the telomerase action at the molecular level.

We also carry out the research which is aimed to study telomerase in higher eukaryotic organisms, human telomerase in particular. There are several questions which are addressed in the laboratory: regulation of the expression of the main telomerase components in human cells, telomerase RNA biogenesis and telomerase alternative functions which are not connected with the telomeric DNA synthesis.

Another direction includes search and creation of telomerase inhibitors and activators. This work is being done in collaboration with the department of Organic chemistry of Lomonosov MSU.

Research result
Results of telomerase investigations

  • The new class of compounds - inhibitors of telomerase was established, it’s an interesting as a potential basis for specific anticancer therapy. [Zvereva M.E. et al, 2011, WIPO Patent Application : WO/2011/126409].

  • The telomerase components of thermotolerant yeast H. polymorpha were identified, the components were isolated in pure and stable condition, which is the base for creating the telomerase system reconstruction. [Smekalova E. M. et al, 2012, Acta Natura].

  • The mechanisms of telomerase activity and telomeres length regulation were established for H. sapiens, H. polymorpha, S. cerevisiae. [Rubtsova M.P et al, 2009, Biochemistry (Mosc)].

  • Telomerase is active as monomer in vitro and biotinylated protein is a component of active telomerase complex in S. Cerevisiae yeasts. [ Shcherbakova D.M. et al, 2009, Biochemistry (Mosc); Shcherbakova D. M. Et al, 2009, Acta Naturae].

  • Biochemical properties and relations of additional protein Est3 S. cerevisiae from the telomerase complex were identify: GTP hydrolysis, specific cooperation with DNA and RNA heteroduplexes and quadruplexes in vitro. [ Shubernetskaya O. et al, 2011, Biochimie; Sharanov Y.S., 2006, FEBS Letters; Malyavko A.G., 2010, Dokl Biochem Biophys].


Results of studies of translation processes

  • The special testing system for antibacterial products was investigated. The system is based on the reporter constructs with dual-fluorescent-protein genes. [Osterman I. A., 2012, Antimicrob Agents Chemother].

  • The number of report constructs (more than 100) were synthesized, in which one of the fluorescent proteins has different 5’- non-coding region, other protein is the control. This system can be very useful for the studying of the translation initiation and reinitiation. [ Sergiev P. V.,2012, Nucleic Acids Res.].

  • The method of purification of 30S ribosomal subunit by streptavidin affinity chromatography was established. [ Golovina A. Y., 2010, Biochimie].

  • It was shown, that C967 and G966 modifications in 16S rRNA help for the E.coli cells adaptaion to the bad conditions. The methyltransferase RsmD methylated G99 16S rRNA was investigated and described. [ Sergeeva O. V., 2012, RNA].

  • The new method of the modification searching was suggested. The basis of the method is the measuring the melting temperature of duplexes from rRNA and labeled DNA-oligonucleotides, which are complementary to the rRNA in the modification position. The first oligonucleotide has the FAM label, second – the BHQ1 quencher, so the building-up of the fluorescence can be fixed. The m7G and m6A modifications can be determined using this method.

  • The SAM-dependent methyltransferase YfiC was identified in E.coli cells. It methylates the N6 atom of the A37 nucleotide tRNAVal. It was shown, that this modification can help cells to survive under the osmotic and oxidation conditions. [Golovina A. Y., 2009, RNA].

Grants and projects
Grants
  • CRDF global (USA);
  • Hovard Hughes Medical Institute grants;
  • Grants of the Ministry of Education and Science of Russian Federation;
  • Grants of the Russian President for the government support to young scientists;
  • RFBR.
Collaboration

  • Max Plank Institute of Biophysical Chemistry, Germany;

  • Max Planck Institute for Molecular Genetics, Germany;

  • Institute of Biotechnology, Lithuania;

  • EMBL, Germany.

Articles

  • Sergiev Petr, Averina Olga, Golubeva Julia, Vyssokikh Mikhail, Dontsova Olga(2025) Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease. Frontiers in Cell and Developmental Biology, >>
  • Guseva Ekaterina, Averina Olga, Isaev Sergey, Pletnev Philipp, Bragina Elizaveta, Permyakov Oleg, Buev Vitaly, Priymak Anastasia, Emelianova Mariia, Pshanichnaya Lizaveta, Romanov Evgeny, Novikova Svetlana E., Petriukov Kirill, Golovina Anna, Grigorieva O(2025) Positioning of sperm tail longitudinal columns depend on Nsun7, an RNA binding protein destabilizing elongated spermatid transcripts. RNA, >>
  • Skvortsov Dmitry, Zhirkina Irina, Ipatova Daria, Vasilyeva Lilya, Ivanenkov Yan, Rubtsova Maria, Kartsev Victor, Sergiev Petr, Dontsova Olga(2025) Co‐Culture Based Screening Revealed Selective Cytostatic Effects of Pyrazol‐Azepinoindoles. ChemMedChem, >>
  • Razumova Elizaveta, Makariuk Aleksandr, Dontsova Olga, Shepelev Nikita, Rubtsova Maria(2025) Structural Features of 5′ Untranslated Region in Translational Control of Eukaryotes. International Journal of Molecular Sciences, >>
  • Rubtsova Maria, Mokrushina Yuliana, Andreev Dmitry, Poteshnova Maria, Shepelev Nikita, Koryagina Mariya, Moiseeva Ekaterina, Malabuiok Diana, Prokopenko Yury, Terekhov Stanislav, Chernov Aleksander, Vodovozova Elena, Smirnov Ivan, Dontsova Olga, Gabibov A(2025) A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines. VACCINES, >>
  • Dontsova Olga A., Nazarenko Anton G., Krupatkin Alexander I., Kuleshov Alexander A., Kleimyonova Elena B., Vetrile Marchel S., Tairov Gazinur N., Zavyalova Elena G., Agina Elena V., Kydralieva Kamilya A., Syrchenko Nikolay V., Khudalov Taimuraz T.(2025) Potential use of SMART implants in traumatology and orthopedics: a review. Вестник травматологии и ортопедии им. Н.Н. Приорова, >>
  • Skvortsov D.A., Zhirkina I.V., Ipatova D.A., Pisarev A.R., Malyshev A.S., Ivanenkov Y.A., Kartsev V.G., Dontsova O.A.(2025) New Kinase Inhibitors That Are Selectively Cytotoxic for Tumor Cells. Doklady Biochemistry and Biophysics, >>
  • Буренина О.Ю., Лазаревич Н.Л., Кустова И.Ф., Шавочкина Д.А., Мороз Е.А., Кудашкин Н.Е., Патютко Ю.И., Рубцова М.П., Донцова О.А.(2025) Upregulation of long noncoding RNAs LINC00941 and ABHD11-AS1 is associated with intrahepatic cholangiocarcinoma. Science Progress, >>
  • Rudenko A.Yu, Mariasina S.S., Ozhiganov R.M., Sergiev P.V., Polshakov V.I.(2025) Enzymatic Reactions of S-Adenosyl-L-Methionine: Synthesis and Applications. Biochemistry (Moscow), >>
  • Nykhrikova Ekaterina V., Kiseleva Marina A., Kalle Paulina, Mariasina Sofia S., Kozyukhin Sergey A., Tatarin Sergei V., Bezzubov Stanislav I.(2025) Stimuli-Responsive Multifunctional Iridium(III) Complex Exhibiting Thermo-, Vapochromism, and Double Catalytic Activity. Inorganic Chemistry, >>
  • Antonenko Yuri N., Rudenko Alexander Y., Khailova Ljudmila S., Firsov Alexander M., Kirsanov Roman S., Lyamzaev Konstantin G., Panteleeva Alisa A., Popova Lyudmila B., Mariasina Sofia S., Kotova Elena A., Polshakov Vladimir I.(2025) Cyazofamid-dessulfonamide (CCIM) is an anionic uncoupler of oxidative phosphorylation in mitochondria and a protonophore on lipid membranes. Biochemical and Biophysical Research Communications, >>
  • Руденко А.Ю., Марьясина С.С., Ожиганов Р.М., Сергиев П.В., В И.Польшаков(2025) Ферментативные реакции S-аденозил-L-метионина: синтез и превращения. Успехи биологической химии, >>
  • Panteleev Pavel V., Pichkur Eugene B., Kruglikov Roman N., Paleskava Alena, Shulenina Olga V., Bolosov Ilia A., Bogdanov Ivan V., Safronova Victoria N., Balandin Sergey V., Marina Valeriya I., Kombarova Tatiana I., Korobova Olga V., Shamova Olga V., Myasn(2024) Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel. Nature communications, >>
  • Tereshchenkov Andrey G., Khairullina Zimfira Z., Volynkina Inna A., Lukianov Dmitrii A., Nazarov Pavel A., Pavlova Julia A., Tashlitsky Vadim N., Razumova Elizaveta A., Ipatova Daria A., Timchenko Yury V., Senko Dmitry A., Efremenkova Olga V., Paleskava A(2024) Triphenylphosphonium Analogs of Short Peptide Related to Bactenecin 7 and Oncocin 112 as Antimicrobial Agents. Pharmaceutics, >>
  • Bolikhova Anastasiia K., Buyan Andrey I., Mariasina Sofia S., Rudenko Alexander Y., Chekh Daria S., Mazur Alexander M., Prokhortchouk Egor B., Dontsova Olga A., Sergiev Petr V.(2024) Study of the RNA splicing kinetics via in vivo 5-ethynyl uridine labelling. RNA, >>
  • Rubtsova M.P., Nikishin D.A., Vyssokikh M.Y., Koriagina M.S., Vasiliev A.V., Dontsova O.A.(2024) Telomere Reprogramming and Cellular Metabolism: Is There a Link?. International Journal of Molecular Sciences, >>
  • ГОЛУБЕВА Ю.А., ГУСЕВА Е.А., ДОНЦОВА О.А., СЕРГИЕВ П.В.(2024) ПРИРОДНЫЕ АКТИВАТОРЫ АУТОФАГИИ. Биохимия, >>
  • ГУСЕВА Е.А., ГОЛУБЕВА Ю.А., ДОНЦОВА О.А., СЕРГИЕВ П.В.(2024) СИНТЕТИЧЕСКИЕ АКТИВАТОРЫ АУТОФАГИИ. Биохимия, >>
  • Pavlova Julia A., Guseva Ekaterina A., Dontsova Olga A., Sergiev Petr V.(2024) Natural Activators of Autophagy. Biochemistry (Moscow), >>
  • Guseva Ekaterina A., Pavlova Julia A., Dontsova Olga A., Sergiev Petr V.(2024) Synthetic Activators of Autophagy. Biochemistry (Moscow), >>
  • Guseva Ekaterina A., Emelianova Maria A., Sidorova Vera N., Tyulpakov Anatoly N., Dontsova Olga A., Sergiev Petr V.(2024) Diversity of Molecular Functions of RNA-Binding Ubiquitin Ligases from the MKRN Protein Family. Biochemistry (Moscow), >>
  • Guseva Ekaterina A., Buev Vitaly S., Mirzaeva Sabina E., Pletnev Philipp I., Dontsova Olga A., Sergiev Petr V.(2024) Structure and Composition of Spermatozoa Fibrous Sheath in Diverse Groups of Metazoa. International Journal of Molecular Sciences, >>
  • Kravchenko Tatyana V., Paramonov Alexander S., Kudzhaev Arsen M., Efimova Svetlana S., Khorev Alexey S., Kudryakova Gulnara Kh, Ivanov Igor A., Chistov Alexey A., Baranova Anna A., Krasilnikov Maxim S., Lapchinskaya Olda A., Tyurin Anton P., Ostroumova Ol(2024) Gausemycin Antibiotic Family Acts via Ca2+-Dependent Membrane Targeting. Journal of Natural Products, >>
  • ШЕПЕЛЕВ Н.М., КУРОЧКИНА А.О., ДОНЦОВА О.А., РУБЦОВА М.П.(2024) МРНК PRPF19 КОДИРУЕТ МАЛУЮ ОТКРЫТУЮ РАМКУ СЧИТЫВАНИЯ, КОТОРАЯ ВАЖНА ДЛЯ ЖИЗНЕСПОСОБНОСТИ КЛЕТОК ЧЕЛОВЕКА. Доклады Российской академии наук. Науки о жизни, >>
  • Deryabin Alexander, Moraleva Anastasiia, Dobrochaeva Kira, Kovaleva Diana, Rubtsova Maria, Dontsova Olga, Rubtsov Yury(2024) Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of Pre-Ribosomal Particles: A Functional Study. Cells, >>
  • Shepelev N.M., Kurochkina A.O., Dontsova O.A., Rubtsova M.P.(2024) PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells. Doklady Biochemistry and Biophysics, >>
  • Petrova Marina, Margasyuk Sergey, Vorobeva Margarita, Skvortsov Dmitry, Dontsova Olga A., Pervouchine Dmitri D.(2024) BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing. NAR Genomics and Bioinformatics, >>
  • Volynkina Inna A., Bychkova Elena N., Karakchieva Anastasiia O., Tikhomirov Alexander S., Zatonsky George V., Solovieva Svetlana E., Martynov Maksim M., Grammatikova Natalia E., Tereshchenkov Andrey G., Paleskava Alena, Konevega Andrey L., Sergiev Petr V.(2024) Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties. Pharmaceuticals, >>
  • Marina Valeriya I., Bidzhieva Medina, Tereshchenkov Andrey G., Orekhov Dmitry, Sagitova Vladislava E., Sumbatyan Nataliya V., Tashlitsky Vadim N., Ferberg Artem S., Maviza Tinashe P., Kasatsky Pavel, Tolicheva Olga, Paleskava Alena, Polshakov Vladimir I.,(2024) An easy tool to monitor the elemental steps of in vitro translation via gel electrophoresis of fluorescently labelled small peptides. RNA, >>
  • Brezgunova Anna A., Andrianova Nadezda V., Saidova Aleena A., Potashnikova Daria M., Abramicheva Polina A., Manskikh Vasily N., Mariasina Sofia S., Pevzner Irina B., Zorova Ljubava D., Manzhulo Igor V., Zorov Dmitry B., Egor Y.Plotnikov(2024) Anti-Inflammatory Effect of Synaptamide in Ischemic Acute Kidney Injury and the Role of G-Protein-Coupled Receptor 110. International Journal of Molecular Sciences, >>
  • Rudenko A.Y., Mariasina S.S., Bolikhova A.K., Nikulin M.V., Ozhiganov R.M., Vasil’ev V.G., Ikhalaynen Y.A., Khandazhinskaya A.L., Khomutov M.A., Sergiev P.V., Khomutov A.R., Polshakov V.I.(2024) Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties. Frontiers in Chemistry, >>
  • Шутов Е.В., Большаков С.А., Федосеева И.А., Сороколетов С.М., Крылова А.С., Тощаков С.В., Марьясина С.С., Булгакова У.В.(2024) Микробиота кишечника и метаболом у больных, получающих перитонеальный диализ. Эффективная фармакотерапия, >>
  • Alferova Vera A., Zotova Polina A., Baranova Anna A., Guglya Elena B., Belozerova Olga A., Pipiya Sofiya O., Kudzhaev Arsen M., Logunov Stepan E., Prokopenko Yuri A., Marenkova Elisaveta A., Marina Valeriya I., Novikova Evgenia A., Komarova Ekaterina S., (2024) Mining Translation Inhibitors by a Unique Peptidyl-Aminonucleoside Synthetase Reveals Cystocin Biosynthesis and Self-Resistance. International Journal of Molecular Sciences, >>
  • Novik Tamara S., Koveshnikova Elena I., Kotlobay Anatoly A., Sycheva Lyudmila P., Kurochkina Karine G., Averina Olga A., Belopolskaya Maria V., Sergiev Petr V., Dontsova Olga A., Lazarev Vassili N., Maev Igor V., Kostyaeva Margarita G., Eremeev Artem V., (2023) Sweet-Tasting Natural Proteins Brazzein and Monellin: Safe Sugar Substitutes for the Food Industry. FOODS, >>
  • Averina Olga A., Permyakov Oleg A., Emelianova Mariia A., Guseva Ekaterina A., Grigoryeva Olga O., Lovat Maxim L., Egorova Anna E., Grinchenko Andrei V., Kumeiko Vadim V., Marey Maria V., Manskikh Vasily N., Dontsova Olga A., Vyssokikh Mikhail Y., Sergiev(2023) Kidney-Related Function of Mitochondrial Protein Mitoregulin. International Journal of Molecular Sciences, >>
  • Averina O.A., Permyakov O.A., Emelianova M.A., Grigoryeva O.O., Lovat M.L., Egorova A.E., Grinchenko A.V., Kumeiko V.V., Marey M.V., Manskikh V.N., Dontsova O.A., Vysokikh M.Y., Sergiev P.V.(2023) Mitoregulin Contributes to Creatine Shuttling and Cardiolipin Protection in Mice Muscle. International Journal of Molecular Sciences, >>
  • Averina Olga A., Permyakov Oleg A., Emelianova Mariia A., Grigoryeva Olga O., Lovat Maxim L., Egorova Anna E., Grinchenko Andrei V., Kumeiko Vadim V., Marey Maria V., Manskikh Vasily N., Dontsova Olga A., Vysokikh Mikhail Yu, Sergiev Petr V.(2023) Mitoregulin Contributes to Creatine Shuttling and Cardiolipin Protection in Mice Muscle. International Journal of Molecular Sciences, >>
  • Pavlova J.A., Tereshchenkov A.G., Nazarov P.A., Lukianov D.A., Skvortsov D.A., Polshakov V.I., Vasilieva B.F., Efremenkova O.V., Kaiumov M.Y., Paleskava A., Konevega A.L., Dontsova O.A., Osterman I.A., Bogdanov A.A., Sumbatyan N.V.(2023) Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents. Antibiotics, >>
  • Машковская А.В., Марьясина С.С., Серебрякова М.В., Рубцова М.П., Донцова О.А., Сергиев П.В.(2023) Проверка метилирования митохондриальной 12S рРНК предполагаемой метилтрансферазой METTL17. Acta Naturae (русскоязычная версия), >>
  • Moraleva Anastasiia, Deryabin Alexander, Kordyukova Maria, Polzikov Mikhail, Shishova Kseniya, Dobrochaeva Kira, Rubtsov Yury, Rubtsova Maria, Dontsova Olga, Zatsepina Olga(2023) Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing. PLoS ONE, >>
  • ШЛЯПИНА В.Л., ДОНЦОВА О.А., РУБЦОВА М.П.(2023) ДЕЛЕЦИЯ НУКЛЕОТИДОВ 184–188 ТЕЛОМЕРАЗНОЙ РНК ЧЕЛОВЕКА НЕ ВЛИЯЕТ НА ФУНКЦИОНИРОВАНИЕ ТЕЛОМЕРАЗЫ. Доклады Российской академии наук. Науки о жизни, >>
  • Shepelev Nikita, Dontsova Olga, Rubtsova Maria(2023) Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres. International Journal of Molecular Sciences, >>
  • Комарова Е.С., Донцова О.А., Пышный Д.В., Кабилов М.Р., Сергиев П.В.(2023) Flow-seq-метод: особенности и применение в изучении бактериальной трансляции. Acta Naturae (русскоязычная версия), >>
  • Komarova Ekaterina S., Dontsova Olga A., Pyshnyi Dmitry V., Kabilov Marsel R., Sergiev Petr V.(2023) Flow-Seq Method: Features and Application in Bacterial Translation Studies. Acta Naturae (англоязычная версия), >>
  • Yanshole Vadim V., Melnikov Arsenty D., Yanshole Lyudmila V., Zelentsova Ekaterina A., Snytnikova Olga A., Osik Nataliya A., Fomenko Maxim V., Savina Ekaterina D., Kalinina Anastasia V., Sharshov Kirill A., Dubovitskiy Nikita A., Kobtsev Mikhail S., Zaiko(2023) Animal Metabolite Database: Metabolite Concentrations in Animal Tissues and Convenient Comparison of Quantitative Metabolomic Data. Metabolites, >>
  • Lavrova Maria A., Verzun Stepan A., Mishurinskiy Sergey A., Sirotin Maxim A., Bykova Sofya K., Gontcharenko Victoria E., Mariasina Sofia S., Korshunov Vladislav M., Taydakov Ilya V., Belousov Yury A., Dolzhenko Vladimir D.(2023) Fine-Tuning of the Optical and Electrochemical Properties of Ruthenium(II) Complexes with 2-Arylbenzimidazoles and 4,4′-Dimethoxycarbonyl-2,2′-bipyridine. Molecules, >>
  • Zelentsova Ekaterina A., Mariasina Sofia S., Yanshole Vadim V., Yanshole Lyudmila V., Osik Nataliya A., Sharshov Kirill A., Tsentalovich Yuri P.(2023) Quantitative Metabolomic Dataset of Avian Eye Lenses. Data, >>
  • Rudenko Alexander Yurievich, Zubarev Andrey Alexandrovich, Ozhiganov Ratislav Maksimovich, Mariasina Sofia Semyonovna, Rodinovskaya Lyudmila Alexandrovna, Sprague Ivan Sanin, Lyssenko Konstantin Alexandrovich, Shestopalov Anatoliy Mikhailovich(2023) Novel combinatorial approach to the synthesis of dihydropyridine (quinoline) based merocyanine dyes. ARKIVOC, >>
  • Ivanova Anastasiia Yu, Shirokov Ivan V., Toshchakov Stepan V., Kozlova Aleksandra D., Obolenskaya Olga N., Mariasina Sofia S., Ivlev Vasily A., Gartseev Ilya B., Medvedev Oleg S.(2023) Effects of Coenzyme Q10 on the Biomarkers (Hydrogen, Methane, SCFA and TMA) and Composition of the Gut Microbiome in Rats. Pharmaceuticals, >>
  • Larionova Tatyana D., Bastola Soniya, Aksinina Tatiana E., Anufrieva Ksenia S., Wang Jia, Shender Victoria O., Andreev Dmitriy E., Kovalenko Tatiana F., Arapidi Georgij P., Shnaider Polina V., Kazakova Anastasia N., Latyshev Yaroslav A., Tatarskiy Victor (2022) Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells. Nature Cell Biology, >>
  • Averina Olga A., Laptev Ivan G., Emelianova Mariia A., Permyakov Oleg A., Mariasina Sofia S., Nikiforova Alyona I., Manskikh Vasily N., Grigorieva Olga O., Bolikhova Anastasia K., Kalabin Gennady A., Dontsova Olga A., Sergiev Petr V.(2022) Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. International Journal of Molecular Sciences, >>
  • Pletnev Philipp I., Shulenina Olga, Evfratov Sergey, Treshin Vsevolod, Subach Maksim F., Serebryakova Marina V., Osterman Ilya A., Paleskava Alena, Bogdanov Alexey A., Dontsova Olga A., Konevega Andrey L., Sergiev Petr V.(2022) Ribosomal protein S18 acetyltransferase RimI is responsible for the acetylation of elongation factor Tu. Journal of Biological Chemistry, >>
  • Burenina O.Y., Lazarevich N.L., Kustova I.F., Zatsepin T.S., Rubtsova M.P., Dontsova O.A.(2022) Expression of CASC8 RNA in Human Pancreatic Cancer Cell Lines. Doklady Biochemistry and Biophysics, >>
  • Buravchenko G.I., Maslov D.A., Alam M.S., Grammatikova N.E., Frolova S.G., Vatlin A.A., Tian X., Ivanov I.V., Bekker O.B., Kryakvin M.A., Dontsova O.A., Danilenko V.N., Zhang T., Shchekotikhin A.E.(2022) Synthesis and Characterization of Novel 2-Acyl-3-trifluoromethylquinoxaline 1,4-Dioxides as Potential Antimicrobial Agents. Pharmaceuticals, >>
  • Komarova Ekaterina S., Slesarchuk Anna N., Rubtsova Maria P., Osterman Ilya A., Tupikin Alexey E., Pyshnyi Dmitry V., Dontsova Olga A., Kabilov Marsel R., Sergiev Petr V.(2022) Flow-Seq Evaluation of Translation Driven by a Set of Natural Escherichia coli 5′-UTR of Variable Length. International Journal of Molecular Sciences, >>
  • Volynkina Inna A., Zakalyukina Yuliya V., Alferova Vera A., Belik Albina R., Yagoda Daria K., Nikandrova Arina A., Buyuklyan Yuliya A., Udalov Andrei V., Golovin Evgenii V., Kryakvin Maxim A., Lukianov Dmitrii A., Biryukov Mikhail V., Sergiev Petr V., Don(2022) Mechanism-Based Approach to New Antibiotic Producers Screening among Actinomycetes in the Course of the Citizen Science Project. Antibiotics, >>
  • Rubtsova Maria, Dontsova Olga(2022) How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript. BIOMEDICINES, >>
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