Departments Department of Cell Signalling

A. N. Belozersky Research Instituteof Physico-Chemical Biology MSU

  2. A. N. Belozersky Research Institute, MSU, Russia
  3. Departments and Laboratories
  4. Departments

Department of Cell Signalling

Leader:

The Department was organized in 1977 (initially as the Department of Enzymology) by professor P.P. Philippov, a follower of Professors S.E. Severin and G.A. Kochetov, who is an unchallenged head of the Department until now.

Research areas

  • Molecular mechanisms of phototransduction and visual signalling proteins
    (Dr. E.Yu. Zernii, Dr. I.I. Senin, Dr. N.K. Tikhomirova).
  • Molecular and cellular mechanisms of degeneration and regeneration of the retina
    (O.S. Gancharova, Prof. P.P. Philippov).
  • Cancer-retina antigens
    (Dr. A.V. Bazhin, Dr. M.S. Savchenko, M.O. Golovastova, Dr. E.E. Skorikova, Prof. P.P. Philippov).

Research results

  • Prediction of the existence of the factor capable of activating transducin GTPase [Arshavsky et al. FEBS Lett. 1989;250:353-6].
  • Discovery of the novel Са2+-binding protein p26 or recoverin [Dizhur A.M., Nekrasova E.R., Filippov P.P. New 26 kDa protein specific for photoreceptor cells, capable of binding with immobilized delipidized rhodopsin. Biokhimiya. 1991;56:225-9; Dizhoor et al. Science. 1991;251:915-8; Ray et al. Proc. Natl. Acad. Sci. USA. 1992;89:5705-9; Dizhoor et al. J. Biol. Chem. 1992;267:16033-6; Dizhoor et al. Science. 1993;259:829-32].
  • Identification of rhodopsin kinase as an intracellular target for recoverin [Gorodovikova EN, Philippov PP. FEBS Lett. 1993;335:277-79; Gorodovikova et al. FEBS Lett. 1994;349:187-90; Gorodovikova EN, Senin II, Philippov PP. FEBS Lett. 1994;353:171-2].
  • Demonstration of the higher efficiency of recoverin as an inhibitor of high gain rhodopsin phosphorylation in comparison with light-dependent phosphorylation [Senin et al. Biochem. J. 1997;320:551-5; Senin II, Zargarov AA, Akhtar M, Philippov PP. FEBS Lett. 1997;408:251-4].
  • Elucidation of the functional role of the specific Са2+-binding centers of recoverin [Alekseev et al. FEBS Lett. 1998;440:116-8; Permyakov et al. Protein Eng. 2000;13:783-90; Fisher T, Senin II, Philippov PP, Koch K-W. Spectroscopy 2002;16:271-79; Senin et al. J. Biol. Chem. 2002;52:50365-72; Weiergräber et al. J. Biol. Chem. 2003;278:22972-9; Senin et al. J. Mol. Biol. 2003;330:409-18].
  • Demonstration of the presence of annexins in mammalian photoreceptors [Zernii et al. Annexins. 2004;1:44-50].
  • Detection of autoantibodies against recoverin (anti-Rc) in sera of patients with lung cancer in the absence of paraneoplastic degeneration of the retina; estimation of the anti-Rc frequencies in sera and expression of recoverin in lung tumors [Bazhin et al. Lung Cancer. 2001;34:99-104; Savchenko et al. Lung Cancer. 2003;41:363-67; Bazhin et al. Lung Cancer. 2004;44:193-8].
  • Elucidation of the modulatory role of the recoverin C-terminal fragment and the mechanism of the Са2+-dependent control of rhodopsin kinase by recoverin [Weiergräber OH et al. Tuning of a neuronal calcium sensor. J. Biol. Chem. 2006;281:37594-602; Senin II et al. Membrane binding of the neuronal calcium sensor recoverin - modulatory role of the charged carboxy-terminus. BMC Biochem. 2007;8:24; Komolov KE et al. Mechanism of rhodopsin kinase regulation by recoverin. J. Neurochem. 2009;110:72-9; Zernii EYu et al. Biochem. J. 2011;435:441-50].
  • Detection of recoverin and other key photoreceptor proteins in malignant tumors different from lung tumors; formulation of the conception of cancer-retina antigens [Bazhin AV et al. Recoverin as a cancer-retina antigen. Cancer Immunol. Immunother. 2007;56:110-6; Bazhin AV et al. Photoreceptor proteins as cancer-retina antigens. Int. J. Cancer. 2007;120:1268-76; Bazhin AV et al. Visible light modulates the expression of cancer-retina antigens. Mol. Cancer Res. 2008;6:110-8; Bazhin AV et al. Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy. Int. J. Cancer. 2009;124:140-9].
  • Demonstration of the functional role of the aberrant expression of transducin and cGMP-phosphodiesterase in melanoma cells [Bazhin AV et al. Cell. Mol. Life Sci. 2010;67:817-28].
  • Estimation of the frequencies of autoantibodies against recoverin and other cancer-retina antigens in sera of patients with various malignant tumors [Savchenko MS et al. Autoantibodies against a Ca2+-binding protein recoverin in blood sera of patients with various oncological diseases. Oncol. Lett. 2012;3:377-82].
  • Demonstration of the role of the aberrant demethylation of the recoverin gene in the aberrant expression of this protein in tumor cells [Bazhin AV et al. Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. Exp. Dermatol. 2010;19:1023-1025].

Grants and projects

Participation in scientific programmes
"Investigation of the visual signalling proteins" jointly with Research Center Jülich and Oldenburg University (Germany); "Investigation of the molecular recognition of visual rhodopsin and rhodopsin kinase" jointly with Polytechnical University of Catalonia and Autonomous University of Barcelona (Spain); "Investigation of the aberrant expression of recoverin in malignant tumors of lung" jointly with Institute of Pulmonology Research Institute, N.N. Blokhin Russian Oncological Scientific Centre, I.M. Setchenov Moscow Medical Academy (Russia), and Philipps-University Marburg (Germany); "Investigation of the effect of antibodies against recoverin upon tumor cells" jointly with Cancer Research Center, University of Heidelberg, and Philipps-University Marburg (Germany); "Investigation of the molecular mechanisms of the aberrant expression of recoverin in malignant tumors" jointly with Brussels Brunch of the Ludwig Institute for Cancer Research (Belgium) and Cancer Research Center, University of Heidelberg (Germany); "Investigation of the aberrant expression of recoverin and other cancer-retina antigens in malignant tumors" jointly with Cancer Research Center and University Hospital Heidelberg, University Heidelberg (Germany).

Grants and stipends
A number of grants from: Russian Foundation for Basic Research and President of Russia; International Human Frontier Science Program; Royal Society and Wellcome Trust (Great Britain); German Research Society for Academic Exchanges, DAAD and German Research Society, DFG (Germany); Ludwig Institute for Cancer Research (USA); Research Center Jülich (Germany); National Center for Scientific Research, CRNS (France); INTAS, and others.

Prizes

Yu.A. Ovchinnikov Award of the Russian Academy of Sciences and Russian Biochemical Society; Stipends of President of Russia and of M.V. Lomonosov Moscow State University.

Educational activity

Training of a number of under- and postgraduate students from Biological and Chemical Faculties, and from Faculty of Bioengineering and Bioinformatics; lecture courses and biochemical workshop for Biological faculty and Faculty of Bioengineering and Bioinformatics.

 

Articles

  • Chistyakov Dmitry V., Belousov Anatolii S., Shevelyova Marina P., Iomdina Elena N., Baksheeva Viktoriia E., Shebardina Natalia G., Moysenovich Anastasia M., Bulgakov Timofey K., Petrov Sergey Yu, Shishkin Mikhail L., Tulush Sanchay S., Tiulina Veronika V.(2025) A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma. Communications Biology, >>
  • Savvateeva Lyudmila V., Chepikova Olga E., Solonkina Alena D., Sakharov Artemiy A., Gorokhovets Neonila V., Golovin Andrey V., Zamyatnin Andrey A.(2025) Computational Screening and Experimental Evaluation of Wheat Proteases for Use in the Enzymatic Therapy of Gluten-Related Disorders. Pharmaceuticals, >>
  • Kostyushev Dmitry S., Zamyatnin Andrey A.(2025) Preface to the Special Issue “Genetic Technologies in Medicine, Agriculture, and Biotechnology”. Biochemistry (Moscow), >>
  • Kuldyushev Nikita A., Simonenko Sergey Y., Goreninskii Semen I., Pallaeva Tatiana N., Zamyatnin Andrey A., Parodi Alessandro(2025) From Nutrient to Nanocarrier: The Multifaceted Role of Vitamin B12 in Drug Delivery. International Journal of Molecular Sciences, >>
  • Kostyusheva Anastasiya, Romano Eugenia, Yan Neng, Lopus Manu, Zamyatnin Andrey A., Parodi Alessandro(2025) Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging. Advanced Drug Delivery Reviews, >>
  • Persano Francesca, Parodi Alessandro, Pallaeva Tatiana, Kolesova Ekaterina, Zamyatnin Andrey A., Pokrovsky Vadim S., De Matteis Valeria, Leporatti Stefano, Cascione Mariafrancesca(2025) Atomic Force Microscopy: A Versatile Tool in Cancer Research. Cancers, >>
  • Тюлина В.В., Лаврушкина С.В., Довгий А.И., Сенин И.И.(2025) Защитное действие кондиционированной среды мезенхимных стволовых клеток костного мозга на роговицу кроликов с нарушением рефлекса моргания. Бюллетень экспериментальной биологии и медицины, >>
  • Chistyakov Dmitry V., Tiulina Veronika V., Gancharova Olga S., Baksheeva Viktoriia E., Goriainov Sergei V., Shebardina Natalia G., Ivlev Vasily A., Komarov Sergey V., Shevelyova Marina P., Tikhomirova Natalia K., Philippov Pavel P., Vasil’ev Vasiliy G., S(2024) Targeting Oxidative Stress and Inflammation in the Eye: Insights from a New Model of Experimental Autoimmune Uveitis. International Journal of Molecular Sciences, >>
  • Belousov Anatoliy, Maslov Ivan, Orekhov Philipp, Khorn Polina, Kuzmichev Pavel, Baleeva Nadezhda, Motov Vladislav, Bogorodskiy Andrey, Krasnova Svetlana, Mineev Konstantin, Zinchenko Dmitry, Zernii Evgeni, Ivanovich Valentin, Permyakov Sergei, Hofkens Joh(2024) Monitoring GPCR Conformation with GFP-Inspired Dyes. iScience, >>
  • Lunegova Daria A., Gvozdev Danil A., Senin Ivan I., Gudkova Victoria R., Sidorenko Svetlana V., Tiulina Veronika V., Shebardina Natalia G., Yakovleva Marina A., Feldman Tatiana B., Ramonova Alla A., Moysenovich Anastasia M., Semenov Alexey N., Zernii Evge(2024) Antioxidant properties of the soluble carotenoprotein AstaP and its feasibility for retinal protection against oxidative stress. FEBS Journal, >>
  • Tikhonov Andrey, Kachanov Artyom, Yudaeva Alexandra, Danilik Oleg, Ponomareva Natalia, Karandashov Ivan, Kostyusheva Anastasiya, Zamyatnin Andrey A., Parodi Alessandro, Chulanov Vladimir, Brezgin Sergey, Kostyushev Dmitry(2024) Biomimetic Nanoparticles for Basic Drug Delivery. Pharmaceutics, >>
  • Brezgin Sergey, Danilik Oleg, Yudaeva Alexandra, Kachanov Artyom, Kostyusheva Anastasiya, Karandashov Ivan, Ponomareva Natalia, Zamyatnin Andrey A., Parodi Alessandro, Chulanov Vladimir, Kostyushev Dmitry(2024) Basic Guide for Approaching Drug Delivery with Extracellular Vesicles. International Journal of Molecular Sciences, >>
  • Kostyusheva Anastasiya, Brezgin Sergey, Ponomareva Natalia, Frolova Anastasiia, Lunin Alexander, Bayurova Ekaterina, Tikhonov Andrey, Slatinskaya Olga, Demina Polina, Kachanov Artyom, Babayeva Gulalek, Khan Irina, Khochenkov Dmitry, Khochenkova Yulia, Sok(2024) Biologics-based technologies for highly efficient and targeted RNA delivery. Molecular Therapy, >>
  • Brezgin Sergey, Frolova Anastasia, Bayurova Ekaterina, Slatinskaya Olga, Ponomareva Natalia, Parshina Evgeniia, Bochkova Zhanna, Kachanov Artyom, Tikhonov Andrey, Kostyusheva Anastasiya, Karandashov Ivan, Demina Polina, Latyshev Oleg, Eliseeva Olesja, Bel(2024) Saponin is Essential for the Isolation of Proteins and RNA from Biological Nanoparticles. ANALYTICAL CHEMISTRY, >>
  • Kalendar Ruslan, Ivanov Konstantin I., Akhmetollayev Ilyas, Kairov Ulykbek, Samuilova Olga, Burster Timo, Zamyatnin Andrey A.(2024) An Improved Method and Device for Nucleic Acid Isolation Using a High-Salt Gel Electroelution Trap. ANALYTICAL CHEMISTRY, >>
  • Zdravkova Kristina, Mijanovic Olja, Brankovic Ana, Ilicheva Polina M., Jakovleva Aleksandra, Karanovic Jelena, Pualic Milena, Pualic Dusan, Rubel Aleksandr A., Savvateeva Lyudmila V., Parodi Alessandro, Zamyatnin Andrey A.(2024) Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets. Cells, >>
  • Kachanov Artyom, Kostyusheva Anastasiya, Brezgin Sergey, Karandashov Ivan, Ponomareva Natalia, Tikhonov Andrey, Lukashev Alexander, Pokrovsky Vadim, Zamyatnin Jr Andrey A., Parodi Alessandro, Chulanov Vladimir, Kostyushev Dmitry(2024) The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution. Medicinal Research Reviews, >>
  • Ponomareva Natalia, Brezgin Sergey, Karandashov Ivan, Kostyusheva Anastasiya, Demina Polina, Slatinskaya Olga, Bayurova Ekaterina, Silachev Denis, Pokrovsky Vadim S., Gegechkori Vladimir, Khaydukov Evgeny, Maksimov Georgy, Frolova Anastasia, Gordeychuk Il(2024) Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment. Pharmaceutics, >>
  • Kutumova Elena O., Akberdin Ilya R., Egorova Vera S., Kolesova Ekaterina P., Parodi Alessandro, Pokrovsky Vadim S., Zamyatnin Jr Andrey A., Kolpakov Fedor A.(2024) Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury. Heliyon, >>
  • Kuznetsova Alyona B., Kolesova Ekaterina P., Parodi Alessandro, Zamyatnin Andrey A., Egorova Vera S.(2024) Reprogramming Tumor-Associated Macrophage Using Nanocarriers: New Perspectives to Halt Cancer Progression. Pharmaceutics, >>
  • Voronina Maya V., Frolova Anastasia S., Kolesova Ekaterina P., Kuldyushev Nikita A., Parodi Alessandro, Zamyatnin Andrey A.(2024) The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy. International Journal of Molecular Sciences, >>
  • Akasov Roman A., Chepikova Olga E., Pallaeva Tatiana N., Gorokhovets Neonila V., Siniavin Andrei E., Gushchin Vladimir A., Savvateeva Lyudmila V., Vinokurov Ivan A., Khochenkov Dmitry A., Zamyatnin Andrey A., Khaydukov Evgeny V.(2024) Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity. Biochimica et Biophysica Acta - General Subjects, >>
  • Parodi Alessandro, Voronina Maya V., Zamyatnin Jr Andrey A.(2024) The Importance of Nanocarriers’ Intra- and Extracellular Degradation:What We Know and Should Know About it?. Current Medicinal Chemistry, >>
  • Tiulina V.V., Senin I.I.(2024) The Quantitative Determination of the Total Antioxidant Activity of Tears. Biochemistry, Supplemental Series B, >>
  • Baksheeva V.E., Zamyatnin A.A., Zernii E.Yu(2023) Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways. Molecular Biology, >>
  • Бакшееваa В.Е., Замятнин А.А., Зерний Е.Ю.(2023) Нейрональный кальциевый сенсор-1: цинк/редоксзависимый белок сигнальных путей нервной системы. Молекулярная биология, >>
  • Baksheeva Viktoriia E., Tiulina Veronika V., Iomdina Elena N., Petrov Sergey Yu, Filippova Olga M., Kushnarevich Nina Yu, Suleiman Elena A., Eyraud Rémi, Devred François, Serebryakova Marina V., Shebardina Natalia G., Chistyakov Dmitry V., Senin Ivan I., (2023) Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma. International Journal of Molecular Sciences, >>
  • Фролова А.С., Тихомирова Н.К., Киреев И.И., Зерний Е.Ю., Пароди А., Иванов К.И., Замятнин А.А.(2023) Экспрессия, внутриклеточная локализация и созревание цистеиновых катепсинов в эмбриональной и опухолевых культурах клеток почки. Биохимия, >>
  • Frolova Anastasia S., Tikhomirova Natalia K., Kireev Igor I., Zernii Evgeni Yu, Parodi Alessandro, Ivanov Konstantin I., Zamyatnin Andrey A.(2023) Expression, Intracellular Localization, and Maturation of Cysteine Cathepsins in Renal Embryonic and Cancer Cell Lines. Biochemistry (Moscow), >>
  • Savvateeva Lyudmila V., Zernii Evgeni Yu, Zamyatnin Andrey A.(2023) Current Perspectives in Ultra-Sensitive Detection of Cancer-Specific Biomarkers and Therapeutic Targets. Current Cancer Drug Targets, >>
  • Нестерович В.М., Белых Д.А., Гороховец Н.В., Курбатов Л.К., Замятнин А.А., Икрянникова Л.Н.(2023) Вторичные метаболиты растений и их возможная роль в “эпоху супербактерий”. Биомедицинская химия, >>
  • Kalendar Ruslan, Ivanov Konstantin I., Samuilova Olga, Kairov Ulykbek, Zamyatnin Andrey A.(2023) Isolation of High-Molecular-Weight DNA for Long-Read Sequencing Using a High-Salt Gel Electroelution Trap. ANALYTICAL CHEMISTRY, >>
  • Rezaei Mahnaz, Ghanadian Mustafa, Ghezelbash Behrooz, Shokouhi Abolfazl, Bazhin Alexandr V., Zamyatnin Andrey A., Ganjalikhani-Hakemi Mazdak(2023) TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines. Frontiers in immunology, >>
  • Gerasimova Elena N., Uvarov Egor, Yaroshenko Vitaly V., Epifanovskaya Olga, Shakirova Alena, Logunov Lev S., Vlasova Olga, Parodi Alessandro, Zamyatnin Andrey A., Timin Alexander S., Makarov Sergey V., Zyuzin Mikhail V.(2023) Single-Step Fabrication of Resonant Silicon–Gold Hybrid Nanoparticles for Efficient Optical Heating and Nanothermometry in Cells. ACS Applied Nano Materials, >>
  • Ivanov Peter A., Gasanova Tatiana V., Repina Maria N., Zamyatnin Andrey A.(2023) Signaling and Resistosome Formation in Plant Innate Immunity to Viruses: Is There a Common Mechanism of Antiviral Resistance Conserved across Kingdoms?. International Journal of Molecular Sciences, >>
  • Zamyatnin Andrey A.(2023) Redox Regulation of Protein Functioning. Biomolecules, >>
  • Sun Jiazheng, Zamyatnin Andrey A., Yuan Xiangliang, Xiao Yi, Li Hongzhong(2023) Editorial: Cancer cell-intrinsic and -extrinsic factors affecting tumor immune evasion. Frontiers in immunology, >>
  • Ivanov Konstantin I., Samuilova Olga V., Zamyatnin Andrey A.(2023) The emerging roles of long noncoding RNAs in lymphatic vascular development and disease. Cellular and Molecular Life Sciences, >>
  • Egorova Vera S., Kolesova Ekaterina P., Lopus Manu, Yan Neng, Parodi Alessandro, Zamyatnin Andrey A.(2023) Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment. Pharmaceutics, >>
  • Kolesova Ekaterina P., Egorova Vera S., Syrocheva Anastasiia O., Frolova Anastasiia S., Kostyushev Dmitry, Kostyusheva Anastasiia, Brezgin Sergey, Trushina Daria B., Fatkhutdinova Landysh, Zyuzin Mikhail, Demina Polina A., Khaydukov Evgeny V., Zamyatnin A(2023) Proteolytic Resistance Determines Albumin Nanoparticle Drug Delivery Properties and Increases Cathepsin B, D, and G Expression. International Journal of Molecular Sciences, >>
  • Ikryannikova Larisa N., Gorokhovets Neonila V., Belykh Darya A., Kurbatov Leonid K., Zamyatnin Andrey A.(2023) Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?. International Journal of Molecular Sciences, >>
  • Frolova Anastasia S., Chepikova Olga E., Deviataikina Anna S., Solonkina Alena D., Zamyatnin Andrey A.(2023) New Perspectives on the Role of Nuclear Proteases in Cell Death Pathways. Biology, >>
  • Soltani Mojdeh, Ghanadian Mustafa, Ghezelbash Behrooz, Shokouhi Abolfazl, Zamyatnin Andrey A., Bazhin Alexandr V., Ganjalikhani-Hakemi Mazdak(2023) PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia. BMC Cancer, >>
  • Kostyushev Dmitry, Brezgin Sergey, Kostyusheva Anastasiya, Ponomareva Natalia, Bayurova Ekaterina, Zakirova Natalia, Kondrashova Alla, Goptar Irina, Nikiforova Anastasiya, Sudina Anna, Babin Yurii, Gordeychuk Ilya, Lukashev Alexander, Zamyatnin Andrey A.,(2023) Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus. Molecular therapy. Nucleic acids, >>
  • Brezgin Sergey, Parodi Alessandro, Kostyusheva Anastasiya, Ponomareva Natalia, Lukashev Alexander, Sokolova Darina, Pokrovsky Vadim S., Slatinskaya Olga, Maksimov Georgy, Zamyatnin Andrey A., Chulanov Vladimir, Kostyushev Dmitry(2023) Technological aspects of manufacturing and analytical control of biological nanoparticles. Biotechnology Advances, >>
  • Kostyushev Dmitry, Kostyusheva Anastasiya, Brezgin Sergey, Ponomareva Natalia, Zakirova Natalia F., Egorshina Aleksandra, Yanvarev Dmitry V., Bayurova Ekaterina, Sudina Anna, Goptar Irina, Nikiforova Anastasiya, Dunaeva Elena, Lisitsa Tatiana, Abramov Iva(2023) Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9. Molecular therapy. Nucleic acids, >>
  • Brezgin Sergey, Kostyusheva Anastasiya, Ponomareva Natalia, Bayurova Ekaterina, Kondrashova Alla, Frolova Anastasia, Slatinskaya Olga, Fatkhutdinova Landysh, Maksimov Georgy, Zyuzin Mikhail, Gordeychuk Ilya, Lukashev Alexander, Makarov Sergey, Ivanov Alex(2023) Hydroxychloroquine Enhances Cytotoxic Properties of Extracellular Vesicles and Extracellular Vesicle–Mimetic Nanovesicles Loaded with Chemotherapeutics. Pharmaceutics, >>
  • Maklakova Svetlana, Lopukhov Anton, Khudyakov Alexandr, Kovalev Sergey V., Mazhuga Maria, Chepikova Olga, Zamyatnin Andrey, Majouga Alexander, Klyachko Natalia L., Beloglazkina Elena K.(2023) Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability. RSC Medicinal Chemistry, >>
  • Tyulina V.V., Senin I.I.(2023) Method for Collection of Tear Fluid for Evaluation Its Antioxidant Properties. Bulletin of Experimental Biology and Medicine, >>
  • Тюлина В.В., Сенин И.И.(2023) Метод получения слёзной жидкости для изучения её антиоксидантных свойств. Бюллетень экспериментальной биологии и медицины, >>
  • Vladimirov Vasiliy I., Shchannikova Margarita P., Baldin Alexey V., Kazakov Alexey S., Shevelyova Marina P., Nazipova Aliya A., Baksheeva Viktoriia E., Nemashkalova Ekaterina L., Frolova Anastasia S., Tikhomirova Natalia K., Philippov Pavel P., Zamyatnin (2022) Redox Regulation of Signaling Complex between Caveolin-1 and Neuronal Calcium Sensor Recoverin. Biomolecules, >>
  • Baksheeva Viktoriia E., Tsvetkov Philipp O., Zalevsky Arthur O., Vladimirov Vasiliy I., Gorokhovets Neonila V., Zinchenko Dmitry V., Permyakov Sergei E., Devred François, Zernii Evgeni Yu(2022) Zinc modulation of neuronal calcium sensor proteins: three modes of interaction with different structural outcomes. Biomolecules, >>
  • Шляпников Ю.М., Малахова Е.А., Винаров А.З., Потолдыкова Н.В., Владимиров В.И., Зерний Е.Ю., Замятнин А.А.мл, Шляпникова Е.А.(2022) Раково-сетчаточные антигены в моче больных раком мочевого пузыря и предстательной железы. Биохимия, >>
  • Shlyapnikov Yuri M., Malakhova Ekaterina A., Vinarov Andrey Z., Potoldykova Natalia V., Vladimirov Vasiliy I., Zernii Evgeni Yu, Zamyatnin Andrey A.Jr, Shlyapnikova Elena A.(2022) Cancer-Retina Antigens in the Urine of Bladder and Prostate Cancer Patients. Biochemistry (Moscow), >>
  • Shlyapnikov Yuri M., Malakhova Ekaterina A., Potoldykova Natalia V., Svetocheva Yana A., Vinarov Andrei Z., Zinchenko Dmitry V., Zernii Evgeni Yu, Zamyatnin Andrey A.Jr, Shlyapnikova Elena A.(2022) Non-invasive kidney cancer diagnostics using ultrasensitive immunodetection of cancer-retina antigens. Biochemistry (Moscow), >>
  • Шляпников Ю.М., Малахова Е.А., Потолдыкова Н.В., Светочева Я.А., Винаров А.З., Зинченко Д.В., Зерний Е.Ю., Замятнин А.А.мл, Шляпникова Е.А.(2022) Неинвазивная диагностика рака почки с помощью ультрачувствительной иммунодетекции раково-сетчаточных антигенов. Биохимия, >>
  • Beloukhova Marina I., Lukashev Alexander N., Volchkov Pavel Y., Zamyatnin Andrey A., Deviatkin Andrei A.(2022) Robust AAV Genotyping Based on Genetic Distances in Rep Gene That Are Maintained by Ubiquitous Recombination. Viruses-Basel, >>
  • Zamyatnin Andrey A., Gregory Levy C., Townsend Paul A., Soond Surinder M.(2022) Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy. Expert Opinion on Therapeutic Targets, >>
  • Petushkova Anastasiia I., Savvateeva Lyudmila V., Zamyatnin Andrey A.(2022) Structure determinants defining the specificity of papain-like cysteine proteases. Computational and Structural Biotechnology Journal, >>
  • Mijanović Olja, Jakovleva Aleksandra, Branković Ana, Zdravkova Kristina, Pualic Milena, Belozerskaya Tatiana A., Nikitkina Angelina I., Parodi Alessandro, Zamyatnin Andrey A.(2022) Cathepsin K in Pathological Conditions and New Therapeutic and Diagnostic Perspectives. International Journal of Molecular Sciences, >>
  • Parodi Alessandro, Kolesova Ekaterina P., Voronina Maya V., Frolova Anastasia S., Kostyushev Dmitry, Trushina Daria B., Akasov Roman, Pallaeva Tatiana, Zamyatnin Andrey A.(2022) Anticancer Nanotherapeutics in Clinical Trials: The Work behind Clinical Translation of Nanomedicine. International Journal of Molecular Sciences, >>
  • Kutumova Elena O., Akberdin Ilya R., Kiselev Ilya N., Sharipov Ruslan N., Egorova Vera S., Syrocheva Anastasiia O., Parodi Alessandro, Zamyatnin Andrey A., Kolpakov Fedor A.(2022) Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools. International Journal of Molecular Sciences, >>
  • Parodi Alessandro, Kostyushev Dmitry, Brezgin Sergey, Kostyusheva Anastasiya, Borodina Tatiana, Akasov Roman, Frolova Anastasia, Chulanov Vladimir, Zamyatnin Andrey A.(2022) Biomimetic approaches for targeting tumor-promoting inflammation. Seminars in Cancer Biology, >>
  • Antishin Anton S., Erdes Svetlana I., Savvateeva Lyudmila V., Soond Surinder M., Zamyatnin Andrey A.(2022) Questionnaire-based survey to determine an at-risk group for coeliac disease among school children in Moscow, Russia. Journal of Paediatrics and Child Health, >>
  • Zamyatnin Andrey A., Parodi Alessandro(2022) New Advances in the Understanding of Proteases as Diagnostic and Pharmaceutical Targets in Homeostatic and Pathologic Conditions. Pharmaceutics, >>
  • Soltani Mojdeh, Savvateeva Lyudmila V., Ganjalikhani-Hakemi Mazdak, Zamyatnin Andrey A.(2022) Clinical Combinatorial Treatments Based on Cancer Vaccines: Combination with Checkpoint Inhibitors and Beyond. Current Drug Targets, >>
  • Rezaei Mahnaz, Danilova Natalia D., Soltani Mozhdeh, Savvateeva Lyudmila V., Tarasov Vadim V., Ganjalikhani-Hakemi Mazdak, Bazhin Alexandr V., Zamyatnin Andrey A.(2022) Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities. Current Cancer Drug Targets, >>
  • Rudzinska-Radecka Magdalena, Frolova Anastasia S., Balakireva Anastasia V., Gorokhovets Neonila V., Pokrovsky Vadim S., Sokolova Darina V., Korolev Dmitry O., Potoldykova Natalia V., Vinarov Andrey Z., Parodi Alessandro, Zamyatnin Andrey A.(2022) In Silico, In Vitro, and Clinical Investigations of Cathepsin B and Stefin A mRNA Expression and a Correlation Analysis in Kidney Cancer. Cells, >>
  • Mikhaylenko Dmitry S., Kuznetsova Ekaterina B., Musatova Viktoria V., Bure Irina V., Deryagina Tatiana A., Alekseeva Ekaterina A., Tarasov Vadim V., Zamyatnin Andrey A., Nemtsova Marina V.(2022) Genetic and Clinical Factors Associated with Olokizumab Treatment in Russian Patients with Rheumatoid Arthritis. Journal of Personalized Medicine, >>
  • Ganjalikhani-Hakemi Mazdak, Xu Ling, Zamyatnin Andrey A., Bazhin Alexandr V.(2022) Editorial: Cellular and Molecular Mechanisms of Immune Checkpoint Blockers in Anti-leukemia/Lymphoma Immune Therapy. Frontiers in oncology, >>
  • Soond Surinder M., Zamyatnin Andrey A.(2022) Helicobacter pylori and gastric cancer: a lysosomal protease perspective. Gastric Cancer, >>
  • Baksheeva Viktoriia E., Roman Andrei Yu, Villard Claude, Devred François, Byrne Deborah, Yatoui Dahbia, Zalevsky Arthur O., Vologzhannikova Alisa A., Sokolov Andrey S., Permyakov Sergei E., Golovin Andrey V., Shaw Gary S., Tsvetkov Philipp O., Zernii Evge(2021) Mechanism of Zn2+ and Ca2+ Binding to Human S100A1. Biomolecules, >>
  • Baksheeva VE, Baldin AV, Zalevsky AO, Nazipova AA, Kazakov AS, Vladimirov VI, Gorokhovets NV, Devred F., Philippov PP, Bazhin AV, Golovin A.V., Zamyatnin AA Jr, Zinchenko DV, Tsvetkov PO, Permyakov SE, Zernii EY(2021) Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling. International Journal of Molecular Sciences, >>
  • Azbukina Nadezhda V., Chistyakov Dmitry V., Goriainov Sergei V., Kotelin Vladislav I., Fedoseeva Elena V., Petrov Sergey Yu, Sergeeva Marina G., Iomdina Elena N., Zernii Evgeni Yu(2021) Targeted Lipidomic Analysis of Aqueous Humor Reveals Signaling Lipid-Mediated Pathways in Primary Open-Angle Glaucoma. Biology, >>
  • Parodi Alessandro, Buzaeva Polina, Nigovora Daria, Baldin Alexey, Kostyushev Dmitry, Chulanov Vladimir, Savvateeva Lyudmila V., Zamyatnin Andrey A.(2021) Nanomedicine for increasing the oral bioavailability of cancer treatments. Journal of Nanobiotechnology, >>
  • Bidram Maryam, Zhao Yue, Shebardina Natalia G., Baldin Alexey V., Bazhin Alexandr V., Ganjalikhany Mohamad Reza, Zamyatnin Andrey A., Ganjalikhani-hakemi Mazdak(2021) mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients. VACCINES, >>
  • Borodina Tatiana, Kostyushev Dmitry, Zamyatnin Andrey A., Parodi Alessandro(2021) Nanomedicine for Treating Diabetic Retinopathy Vascular Degeneration. International Journal of Translational Medicine, >>
  • Abakushina Elena V., Popova Liubov I., Zamyatnin Andrey A., Werner Jens, Mikhailovsky Nikolay V., Bazhin Alexandr V.(2021) The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy. VACCINES, >>
  • Zamyatnin Alexander A., Belozerskaya Tatiana A., Zamyatnin Andrey A.(2021) Taxonomy of Mitochondrial Cytochrome B Proteins of the Same Amino Acid Sequence Length. Scientific World Journal, >>
  • Townsend Paul A., Kozhevnikova Maria V., Cexus Olivier N.F., Zamyatnin Andrey A., Soond Surinder M.(2021) BH3-mimetics: recent developments in cancer therapy. Journal of Experimental and Clinical Cancer Research, >>
  • Machulkin Aleksei E., Uspenskaya Anastasia A., Zyk Nikolay U., Nimenko Ekaterina A., Ber Anton P., Petrov Stanislav A., Polshakov Vladimir I., Shafikov Radik R., Skvortsov Dmitry A., Plotnikova Ekaterina A., Pankratov Andrei A., Smirnova Galina B., Boriso(2021) Synthesis, characterization and preclinical evaluation of small-molecule prostate-specific membrane antigen targeted monomethyl auristatin E conjugate. Journal of Medicinal Chemistry, >>
  • Lin Sisi, Kühn Florian, Schiergens Tobias S., Zamyatnin Andrey A., Isayev Orkhan, Gasimov Eldar, Werner Jens, Li Yongyu, Bazhin Alexandr V.(2021) Experimental postoperative ileus: is Th2 immune response involved?. International Journal of Medical Sciences, >>
  • Mijanovic Olja, Petushkova Anastasiia I., Brankovic Ana, Turk Boris, Solovieva Anna B., Nikitina Angelina I., Bolevich Sergey, Timashev Peter S., Parodi Alessandro, Zamyatnin Andrey A.(2021) Cathepsin D—Managing the Delicate Balance. Pharmaceutics, >>
  • Vetchinkina Ekaterina A., Mikhaylenko Dmitry S., Kuznetsova Ekaterina B., Deryagina Tatiana A., Alekseeva Ekaterina A., Bure Irina V., Zamyatnin Andrey A., Nemtsova Marina V.(2021) Genetic Factors of Predisposition and Clinical Characteristics of Rheumatoid Arthritis in Russian Patients. Journal of Personalized Medicine, >>
  • Korneyenkov Maxim A., Zamyatnin Andrey A.(2021) Next Step in Gene Delivery: Modern Approaches and Further Perspectives of AAV Tropism Modification. Pharmaceutics, >>
  • Soond Surinder M., Kozhevnikova Maria V., Savvateeva Lyudmila V., Townsend Paul A., Zamyatnin Andrey A.(2021) Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis. International Journal of Molecular Sciences, >>
  • Rudzinska Magdalena, Czarnecka-Chrebelska Karolina H., Kuznetsova Ekaterina B., Maryanchik Sofya V., Parodi Alessandro, Korolev Dmitry O., Potoldykova Nataliya, Svetikova Yulia, Vinarov Andrey Z., Nemtsova Marina V., Zamyatnin Andrey A.(2021) Long Non-Coding PROX1-AS1 Expression Correlates with Renal Cell Carcinoma Metastasis and Aggressiveness. Non-Coding RNA, >>
  • ALMEIDA MARCELLE O., VIANA MARCUS V.C., CERQUEIRA JANAÍNA C., ABURJAILE FLAVIA F., ZAMYATNIN ANDREY A., AZEVEDO VASCO, CARVALHO RODRIGO D.O.(2021) Novel insights in bacterial vaginosis etiology through genomic approaches. Anais da Academia Brasileira de Ciencias, >>
  • Soond Surinder M., Savvateeva Lyudmila V., Makarov Vladimir A., Gorokhovets Neonila V., Townsend Paul A., Zamyatnin Andrey A.(2021) Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis. Pharmaceutics, >>
  • Shlyapnikov Yuri M., Malakhova Ekaterina A., Vinarov Andrey Z., Zamyatnin Andrey A.Jr, Shlyapnikova Elena A.(2021) Can new immunoassay techniques improve bladder cancer diagnostics With protein biomarkers?. Frontiers in Molecular Biosciences, >>
  • Carvalho Rodrigo, Aburjaile Flavia, Canario Marcus, Nascimento Andréa M.A., Chartone-Souza Edmar, de Jesus Luis, Zamyatnin Andrey A., Brenig Bertram, Barh Debmalya, Ghosh Preetam, Goes-Neto Aristoteles, Figueiredo Henrique C.P., Soares Siomar, Ramos Romme(2021) Genomic Characterization of Multidrug-Resistant Escherichia coli BH100 Sub-strains. Frontiers in microbiology, >>
  • Rudzińska Magdalena, Daglioglu Cenk, Savvateeva Lyudmila V., Kaci Fatma Necmiye, Antoine Rodolphe, Zamyatnin Jr Andrey A.(2021) Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy. Drug Design, Development and Therapy, >>

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